9.17 - Protein–Polymer Conjugates

Z. P. Tolstyka, H. D. Maynard

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Bioconjugates are increasingly important in the fields of biotechnology, nanotechnology, and medicine. These hybrid materials consist of a synthetic macromolecule linked to a biomolecule such as a peptide or protein. Both the method used to produce the synthetic molecule and the technique of attachment to the biomolecule are important to the overall properties of the biohybrid. This chapter focuses on this emerging field of biotechnology and on the use of two controlled radical polymerization techniques, atom transfer radical polymerization and reversible addition-fragmentation chain transfer polymerization, to create protein–polymer conjugates. The techniques of grafting to and grafting from are summarized, along with application of the resulting conjugates as therapeutics and nanocapsules.

Original languageEnglish (US)
Title of host publicationPolymer Science
Subtitle of host publicationa Comprehensive Reference: Volume 1-10
PublisherElsevier
Pages317-337
Number of pages21
Volume1-10
ISBN (Electronic)9780080878621
DOIs
StatePublished - Jan 1 2012

Bibliographical note

Publisher Copyright:
© 2012 Elsevier B.V. All rights reserved.

Keywords

  • Atom transfer radical polymerization
  • Bioconjugation
  • Biotechnology
  • Controlled radical polymerization
  • Grafting from
  • Grafting to
  • PEGylation
  • Poly(ethylene glycol)
  • Protein–polymer conjugate
  • Reversible addition-fragmentation chain transfer polymerization
  • Site-selective conjugation
  • Therapeutic

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