9,11-AZO-13-OXA-15-hydroxyprostanoic acid: A potent thromboxane synthetase inhibitor and a pgh2/txa2 receptor antagonist

Sheung Tsam Kam, Philip S. Portoghese, Earl W. Dunham, Jonathan M. Gerrard

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

9,11-Azo-13-oxa-15-hydroxyprostanoic acid (AOHP) is shown to be _a potent inhibitor of thromboxane synthetase with an IC50 at about 10-6M. It also blocked the agonist actions of 9,11-epoxymethano-PGH2 IC50 9 × 10-7M) and TXA2 IC50 2.4 × 10-6M) on human platelet-rich plasma indicating that it also is a PGH2/TxA2 receptor blocker.

Original languageEnglish (US)
Pages (from-to)279-289
Number of pages11
JournalProstaglandines and Medicine
Volume3
Issue number5
DOIs
StatePublished - Nov 1979

Bibliographical note

Funding Information:
This work was supported in part by NIH research grant HL 16524 and HL 17871 and is abstracted in part from the Ph.D. thesis submitted by S. -T. Kam to the Graduate Faculty, University of Minnesota. The authors wish to thank Dr. G. Graff, Department of Pharmacology, University of Minnesota, for the [l-14C]PGH2 sample and Dr. J. E. Pike of the Upjohn Company for the prostaglandin standards.

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