9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma

Keyphrases

• Pharmacokinetics 100%
• Amino 100%
• In Vivo Efficacy 100%
• In Vitro-in Vivo 100%
• Brain Distribution 100%
• Malignant Glioma 100%
• Acridine 100%
• Methyl 66%
• Peak Concentration 66%
• Methanone 66%
• Peak Plasma Concentration 66%
• Pharmacokinetic Study 33%
• Mouse Model 33%
• Blood-brain Barrier 33%
• Cancer Cell Lines 33%
• Brain Cancer 33%
• Glioma 33%
• Metabolism 33%
• Drug Delivery 33%
• Topoisomerase II 33%
• Glioma Cells 33%
• Cell Death 33%
• Oral Dose 33%
• Apoptosis 33%
• Oral Bioavailability 33%
• Catalytic Cycle 33%
• ED50 33%
• Pharmacokinetic Data 33%
• Compound 9 33%
• Plasma Protein Binding 33%
• Benzyl 33%
• Improved Efficacy 33%
• Indol 33%
• In Vivo Activity 33%
• Metabolic Stability 33%
• Efflux Transport 33%
• Piperidin 33%
• Absorption Distribution 33%
• Orthotopic Glioma 33%
• Mouse Pharmacokinetics 33%
• Intravenous Dose 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Glioblastoma 100%
• Acridine 100%
• Pharmacokinetics 100%
• Bioavailability 40%
• Piperazine 40%
• Mouse Model 20%
• Malignant Neoplasm 20%
• Brain Cancer 20%
• Effusion 20%
• Lead Compound 20%
• Indole 20%
• DNA Topoisomerase (ATP Hydrolysing) 20%
• Plasma Protein Binding 20%
• Blood-Brain Barrier 20%