7T MRI and Computational Modeling Supports a Critical Role of Lead Location in Determining Outcomes for Deep Brain Stimulation: A Case Report

Lauren E. Schrock, Remi Patriat, Mojgan Goftari, Jiwon Kim, Matthew D. Johnson, Noam Harel, Jerrold L. Vitek

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established therapy for Parkinson’s disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead “anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the STN (based on stereotactic atlas coordinates) produces similar clinical efficacy.” These discrepancies likely result from methodological differences including targeting preferences, imaging acquisition and the use of brain atlases that do not account for patient-specific anatomic variability. We present a first-in-kind within-patient demonstration of severe mood side effects and minimal motor improvement in a Parkinson’s disease patient following placement of a DBS lead in the limbic/associative territory of the STN who experienced marked improvement in motor benefit and resolution of mood side effects following repositioning the lead within the STN sensorimotor territory. 7 Tesla (7 T) magnetic resonance imaging (MRI) data were used to generate a patient-specific anatomical model of the STN with parcellation into distinct functional territories and computational modeling to assess the relative degree of activation of motor, associative and limbic territories.

Original languageEnglish (US)
Article number631778
JournalFrontiers in Human Neuroscience
StatePublished - Feb 11 2021

Bibliographical note

Funding Information:
This work was supported by the University of Minnesota Udall Center, National Institute of Neurological Disorders and Stroke (Award Number: P50-NS098573) as well as the following grants: R01-NS081118, R01-NS113746, P41-EB027061, P30-NS076408, and R01-NS094206.

Publisher Copyright:
© Copyright © 2021 Schrock, Patriat, Goftari, Kim, Johnson, Harel and Vitek.


  • Parkinson’s disease
  • case report
  • computational modeling
  • deep brain stimulation
  • electrode location
  • subthalamic nucleus
  • ultra-high field MRI

Center for Magnetic Resonance Research (CMRR) tags

  • NM
  • P41

PubMed: MeSH publication types

  • Case Reports


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