6-trifluoromethylpyridoxine: Novel 19F NMR pH indicator for in vivo detection

Jian Xin Yu, Weina Cui, Vincent A. Bourke, Ralph P. Mason

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

pH plays an important role in tumor proliferation, angiogenesis, metabolic control, and the efficacy of cytotoxic therapy, and accurate noninvasive assessment of tumor pH promises to provide insight into developmental processes and prognostic information. In this paper, we report the design, synthesis, and characterization of two novel pH indicators 6-trifluoromethylpyridoxine 8 and α 45-di-O-[3′-O-(β-d- glucopyranosyl)propyl]-6-trifluoromethylpyridoxine 17 and demonstrate 8 as an extracellular 19F NMR pH probe to assess pH e of various tumors in vivo.

Original languageEnglish (US)
Pages (from-to)6814-6821
Number of pages8
JournalJournal of medicinal chemistry
Volume55
Issue number15
DOIs
StatePublished - Aug 9 2012

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