[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A 4 hydrolase

Chul Ho Jeong, Ann M. Bode, Angelo Pugliese, Yong Yeon Cho, HONGGYUM KIM, Jung Hyun Shim, Young J Jeon, Honglin Li, Hualiang Jiang, Zigang Dong

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118 Scopus citations

Abstract

[6]-Gingerol, a natural component of ginger, exhibits antiinflammatory and antitumorigenic activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts its chemopreventive effects remains elusive. The leukotriene A4 hydrolase (LTA4H) protein is regarded as a relevant target for cancer therapy. Our in silico prediction using a reverse-docking approach revealed that LTA4H might be a potential target of [6]-gingerol. We supported our prediction by showing that [6]-gingerol suppresses anchorage-independent cancer cell growth by inhibiting LTA 4H activity in HCT116 colorectal cancer cells. We showed that [6]-gingerol effectively suppressed tumor growth in vivo in nude mice, an effect that was mediated by inhibition of LTA4H activity. Collectively, these findings indicate a crucial role of LTA4H in cancer and also support the anticancer efficacy of [6]-gingerol targeting of LTA4H for the prevention of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)5584-5591
Number of pages8
JournalCancer Research
Volume69
Issue number13
DOIs
StatePublished - Jul 1 2009

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    Jeong, C. H., Bode, A. M., Pugliese, A., Cho, Y. Y., KIM, HONGGYUM., Shim, J. H., Jeon, Y. J., Li, H., Jiang, H., & Dong, Z. (2009). [6]-Gingerol suppresses colon cancer growth by targeting leukotriene A 4 hydrolase. Cancer Research, 69(13), 5584-5591. https://doi.org/10.1158/0008-5472.CAN-09-0491