6-Deoxycarbovir: A Xanthine Oxidase Activated Prodrug Of Carbovir

Robert Vince, Jay Brownell, Scott A. Beers

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

(-)-(cis)-4-(2-Amino-9H-purin-9-yl)-2-cyclopentenyl carbinol (6-deoxycarbovir) was prepared in order to evaluate prodrug approaches to increased bioavailability of the anti-HIV agent, (-)-carbovir. Incubation experiments demonstrated that 6-deoxycarbovir was rapidly converted to (-)-carbovir by the enzyme, xanthine oxidase. Since xanthine oxidase activity is present in both the intestine and liver, a high first pass conversion to carbovir would be expected in vivo.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalNucleosides and Nucleotides
Volume14
Issue number1-2
DOIs
StatePublished - Feb 1 1995

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