5-Hz stimulation of CA3 pyramidal cell axons induces a β-adrenergic modulated potentiation at synapses on CA1, but not CA3, pyramidal cells

Teena D. Moody, Mark J Thomas, Michael Makhinson, Thomas J. O'Dell

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

In mouse hippocampal slices, long-term potentiation (LTP) at Schaffer collateral fiber synapses onto CA1 pyramidal cells could be induced by brief trains of 5-Hz synaptic stimulation (30 s) or by longer trains of 5-Hz stimulation (3 min) delivered during β-adrenergic receptor activation. In contrast, 5-Hz stimulation, either alone or in the presence of the β- adrenergic receptor agonist isoproterenol, failed to induce LTP at associational-commissural (assoc-com) fiber synapses onto CA3 pyramidal cells. Our results suggest that although CA3 pyramidal cells give rise to both the Schaffer collateral fiber synapses in CA1 and the assoc-com fiber synapses in CA3, the induction of LTP at these synapses may be regulated by different activity- and modulatory neurotransmitter-dependent processes.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalBrain Research
Volume794
Issue number1
DOIs
StatePublished - May 25 1998
Externally publishedYes

Keywords

  • Hippocampus
  • Long-term potentiation
  • β-adrenergic

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