5-Fluorouracil after Trabeculectomy and the Iridocorneal Endothelial Syndrome

Martha M. Wright, Alana L. Grajewski, Stephen M. Cristol, Richard K. Parrish

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28 Scopus citations


Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53.8 mg). Eight eyes had undergone prior unsuccessful trabeculectomy. Four eyes had intraocular pressure (IOP) less than or equal to 21 mmHg on zero to two glaucoma medications after 6 to 54 months of follow-up (mean, 25.3 months). Five eyes required repeat surgery within 2 to 13 months and were considered failures. All five eyes that failed received a Molteno drainage implant. Progressive endothelial proliferation may explain late onset bleb failure and the relative ineffectiveness of 5-FU in this condition.

Original languageEnglish (US)
Pages (from-to)314-316
Number of pages3
Issue number3
StatePublished - 1991

Bibliographical note

Funding Information:
Supported in part by Public Health SeNice Research Grant EY07021 and in part by grant EY02180, Department of Health and Human SeNices, National Institutes of Health, National Eye Institute, Bethesda, Maryland.


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