5-azacytidine-induced increase in plasma prolactin levels of immature turkeys.

S. C. Fehrer; J. L. Silsby; M E Elhalawani; K. S. Guise

doi:10.3382/ps.0671794

5-azacytidine-induced increase in plasma prolactin levels of immature turkeys.

S. C. Fehrer, J. L. Silsby, M E Elhalawani, K. S. Guise

Animal Science

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Abstract

Immature female turkeys (7 wk old) were treated with 5-azacytidine, a cytidine analog that has been shown to inhibit cytosine methylation in eukaryotic DNA. Such methylation has been repeatedly implicated in the control of specific gene expression in higher vertebrates. Turkeys administered 5-azacytidine (5 mg/kg) by intravenous injection daily for 5 days exhibited elevated (P less than .05) circulating prolactin (Prl) levels, whereas hens treated with saline, cytidine, or 6-azathymine did not show altered circulating Prl levels. Absence of response upon treatment with the normal nucleoside cytidine or the 6-aza analog of thymine reasonably eliminates nonspecific drug-induced stress as the cause of Prl level elevation. Based on these findings, DNA methylation is implicated in the control of circulating Prl levels in the young turkey.

Original language	English (US)
Pages (from-to)	1794-1796
Number of pages	3
Journal	Poultry science
Volume	67
Issue number	12
DOIs	https://doi.org/10.3382/ps.0671794
State	Published - Dec 1988

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title = "5-azacytidine-induced increase in plasma prolactin levels of immature turkeys.",

abstract = "Immature female turkeys (7 wk old) were treated with 5-azacytidine, a cytidine analog that has been shown to inhibit cytosine methylation in eukaryotic DNA. Such methylation has been repeatedly implicated in the control of specific gene expression in higher vertebrates. Turkeys administered 5-azacytidine (5 mg/kg) by intravenous injection daily for 5 days exhibited elevated (P less than .05) circulating prolactin (Prl) levels, whereas hens treated with saline, cytidine, or 6-azathymine did not show altered circulating Prl levels. Absence of response upon treatment with the normal nucleoside cytidine or the 6-aza analog of thymine reasonably eliminates nonspecific drug-induced stress as the cause of Prl level elevation. Based on these findings, DNA methylation is implicated in the control of circulating Prl levels in the young turkey.",

author = "Fehrer, {S. C.} and Silsby, {J. L.} and Elhalawani, {M E} and Guise, {K. S.}",

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AU - Fehrer, S. C.

AU - Silsby, J. L.

AU - Elhalawani, M E

AU - Guise, K. S.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 1988/12

Y1 - 1988/12

N2 - Immature female turkeys (7 wk old) were treated with 5-azacytidine, a cytidine analog that has been shown to inhibit cytosine methylation in eukaryotic DNA. Such methylation has been repeatedly implicated in the control of specific gene expression in higher vertebrates. Turkeys administered 5-azacytidine (5 mg/kg) by intravenous injection daily for 5 days exhibited elevated (P less than .05) circulating prolactin (Prl) levels, whereas hens treated with saline, cytidine, or 6-azathymine did not show altered circulating Prl levels. Absence of response upon treatment with the normal nucleoside cytidine or the 6-aza analog of thymine reasonably eliminates nonspecific drug-induced stress as the cause of Prl level elevation. Based on these findings, DNA methylation is implicated in the control of circulating Prl levels in the young turkey.

AB - Immature female turkeys (7 wk old) were treated with 5-azacytidine, a cytidine analog that has been shown to inhibit cytosine methylation in eukaryotic DNA. Such methylation has been repeatedly implicated in the control of specific gene expression in higher vertebrates. Turkeys administered 5-azacytidine (5 mg/kg) by intravenous injection daily for 5 days exhibited elevated (P less than .05) circulating prolactin (Prl) levels, whereas hens treated with saline, cytidine, or 6-azathymine did not show altered circulating Prl levels. Absence of response upon treatment with the normal nucleoside cytidine or the 6-aza analog of thymine reasonably eliminates nonspecific drug-induced stress as the cause of Prl level elevation. Based on these findings, DNA methylation is implicated in the control of circulating Prl levels in the young turkey.

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5-azacytidine-induced increase in plasma prolactin levels of immature turkeys.

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