TY - JOUR
T1 - 5-Aminosalicylic Acid attenuates allergen-induced airway inflammation and oxidative stress in asthma
AU - Raju, K. Rama Satyanarayana
AU - Kumar, M. N.Sathish
AU - Gupta, Saurabh
AU - Naga, Srinivas T.
AU - Shankar, Jaya K.
AU - Murthy, Vishakantha
AU - Madhunapanthula, Subba Rao V.
AU - Mulukutla, Shashank
AU - Ambhore, Nilesh S.
AU - Tummala, Shashank
AU - Vishnuvarthan, V. J.
AU - Azam, Afzal
AU - Elango, Kannan
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014
Y1 - 2014
N2 - Pro-inflammatory cytokines regulate the magnitude of allergic reactions during asthma. Tumor necrosis factor - alpha (TNF-α), interleukin-6 (IL-6) and interleukin-13 (IL-13) play a crucial role in aggravating the inflammatory conditions during allergic asthma. In addition, oxidative stress contributes to the pathogenesis of asthma by altering the physiological condition resulting in the development of status asthmaticus. Anti-inflammatory corticosteroids are being widely used for treating allergic asthma. In the present study 5-aminosalicylic acid (5-ASA), a salicylic acid derivative, was evaluated, invivo for its potential to suppress TNF-α, IL-6 and IL-13 using ovalbumin (OVA) induced allergic asthma in Balb/C mice. Oral administration of 65, 130 and 195mg/kg 5-ASA significantly reduced the OVA induced total and differential leucocyte count, TNF-α, IL-6, IL-13, nitrite, nitrate, MDA, MPO and TPL levels in the lung lavage samples. Collectively, these findings suggest that 5-ASA is a potent immunomodulator and suppresses key Th2 cytokines production and oxidative stress in OVA-induced asthma.
AB - Pro-inflammatory cytokines regulate the magnitude of allergic reactions during asthma. Tumor necrosis factor - alpha (TNF-α), interleukin-6 (IL-6) and interleukin-13 (IL-13) play a crucial role in aggravating the inflammatory conditions during allergic asthma. In addition, oxidative stress contributes to the pathogenesis of asthma by altering the physiological condition resulting in the development of status asthmaticus. Anti-inflammatory corticosteroids are being widely used for treating allergic asthma. In the present study 5-aminosalicylic acid (5-ASA), a salicylic acid derivative, was evaluated, invivo for its potential to suppress TNF-α, IL-6 and IL-13 using ovalbumin (OVA) induced allergic asthma in Balb/C mice. Oral administration of 65, 130 and 195mg/kg 5-ASA significantly reduced the OVA induced total and differential leucocyte count, TNF-α, IL-6, IL-13, nitrite, nitrate, MDA, MPO and TPL levels in the lung lavage samples. Collectively, these findings suggest that 5-ASA is a potent immunomodulator and suppresses key Th2 cytokines production and oxidative stress in OVA-induced asthma.
KW - 5-Aminosalicylic acid
KW - Allergic asthma
KW - Inflammation
KW - Oxidative stress
KW - Proinflammatory cytokines
UR - https://www.scopus.com/pages/publications/84922547423
UR - https://www.scopus.com/pages/publications/84922547423#tab=citedBy
U2 - 10.1016/j.pupt.2014.07.007
DO - 10.1016/j.pupt.2014.07.007
M3 - Article
C2 - 25101553
AN - SCOPUS:84922547423
SN - 1094-5539
VL - 29
SP - 209
EP - 216
JO - Pulmonary Pharmacology and Therapeutics
JF - Pulmonary Pharmacology and Therapeutics
IS - 2
ER -
