4,7-disubstituted 7h-pyrrolo[2,3-d]pyrimidines and their analogs as antiviral agents against zika virus

Research output: Contribution to journalArticlepeer-review

Abstract

Discovery of compound 1 as a Zika virus (ZIKV) inhibitor has prompted us to investigate its 7H-pyrrolo[2,3-d]pyrimidine scaffold, revealing structural features that elicit antiviral activity. Furthermore, we have demonstrated that 9H-purine or 1H-pyrazolo[3,4-d]pyrimidine can serve as an alternative core structure. Overall, we have identified 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs including compounds 1, 8 and 11 as promising antiviral agents against flaviviruses ZIKV and dengue virus (DENV). While the molecular target of these compounds is yet to be elucidated, 4,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidines and their analogs are new chemotypes in the design of small molecules against flaviviruses, an important group of human pathogens.

Original languageEnglish (US)
Article number3779
JournalMolecules
Volume26
Issue number13
DOIs
StatePublished - Jun 22 2021

Bibliographical note

Funding Information:
Funding: This research was funded by the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, grant number R21AI151427 (to LC) and a University of Minnesota Academic Health Center Faculty Research Development Grant (to RJG).

Funding Information:
This research was funded by the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, grant number R21AI151427 (to LC) and a University of Minnesota Academic Health Center Faculty Research Development Grant (to RJG). Acknowledgments: We thank Paul D. Robbins and Fernando Santiago from the UMN Department of Biochemistry, Molecular Biology and Biophysics for the use of the Cytation One imaging system.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Antiviral agents
  • Dengue virus
  • Flavivirus
  • Zika virus

PubMed: MeSH publication types

  • Journal Article

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