4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.
|Original language||English (US)|
|Number of pages||3|
|Journal||Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism|
|State||Published - Mar 12 1990|
Bibliographical noteFunding Information:
This work was supported by a grant from the Niels Stensen Foundation (The Netherlands) (to F.J.G.M. v.K.) and by grant No. ROl-EY06913 from the USA National Eye Institute (to E.A.D.).
- Docosahexaenoic acid
- Lipid peroxidation