4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

Frederik J.G.M. Van Kuijk, Laura L. Holte, Edward A. Dratz

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Issue number1
StatePublished - Mar 12 1990

Bibliographical note

Funding Information:
This work was supported by a grant from the Niels Stensen Foundation (The Netherlands) (to F.J.G.M. v.K.) and by grant No. ROl-EY06913 from the USA National Eye Institute (to E.A.D.).


  • 4-Hydroxyhexenal
  • 4-Hydroxynonenal
  • Docosahexaenoic acid
  • Lipid peroxidation


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