4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

Apurba Datta; Lalith R. Jayasinghe; Gunda I. Georg

doi:10.1021/jm00050a023

4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

Apurba Datta
, Lalith R. Jayasinghe
, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.

Original language	English (US)
Pages (from-to)	4258-4260
Number of pages	3
Journal	Journal of medicinal chemistry
Volume	37
Issue number	24
DOIs	https://doi.org/10.1021/jm00050a023
State	Published - Nov 1 1994

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1021/jm00050a023

Find It

Find It at U of M Libraries

Cite this

@article{9f0cc51768d446e38c3a748084a91bb6,

title = "4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation",

abstract = "4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.",

author = "Apurba Datta and Jayasinghe, \{Lalith R.\} and Georg, \{Gunda I.\}",

year = "1994",

month = nov,

day = "1",

doi = "10.1021/jm00050a023",

language = "English (US)",

volume = "37",

pages = "4258--4260",

journal = "Journal of medicinal chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "24",

}

TY - JOUR

T1 - 4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere

T2 - Synthesis and Biological Evaluation

AU - Datta, Apurba

AU - Jayasinghe, Lalith R.

AU - Georg, Gunda I.

PY - 1994/11/1

Y1 - 1994/11/1

N2 - 4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.

AB - 4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.

UR - https://www.scopus.com/pages/publications/0028080038

UR - https://www.scopus.com/pages/publications/0028080038#tab=citedBy

U2 - 10.1021/jm00050a023

DO - 10.1021/jm00050a023

M3 - Article

C2 - 7990125

AN - SCOPUS:0028080038

SN - 0022-2623

VL - 37

SP - 4258

EP - 4260

JO - Journal of medicinal chemistry

JF - Journal of medicinal chemistry

IS - 24

ER -

4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

Abstract

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this