3D reconstruction of microvascular flow phantoms with hybrid imaging modalities

Jingying Lin, Kevin Hsiung, Russell Ritenour, Jafar Golzarian

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Microvascular flow phantoms were built to aid the development of a hemodynamic simulation model for treating hepatocelluar carcinoma. The goal is to predict the blood flow routing for embolotherapy planning. Embolization is to deliver agents (e.g. microspheres) to the vicinity of the tumor to obstruct blood supply and nutrients to the tumor, targeting into 30 - 40 μm arterioles. Due to the size of the catheter, it has to release microspheres at an upper stream location, which may not localize the blocking effect. Accurate anatomical descriptions of microvasculature will help to conduct a reliable simulation and prepare a successful embolization strategy. Modern imaging devices can generate 3D reconstructions with ease. However, with a fixed detector size, larger field of view yields lower resolution. Clinical CT images can't be used to measure micro vessel dimensions, while micro-CT requires more acquisitions to reconstruct larger vessels. A multi-tiered, montage 3D reconstruction method with hybrid-modality imagery is devised to minimize the reconstruction effort. Regular CT is used for larger vessels and micro-CT is used for micro vessels. The montage approach aims to stitch up images with different resolutions and orientations. A resolution-adaptable 3D image registration is developed to assemble the images. We have created vessel phantoms that consist of several tiers of bifurcating polymer tubes in reducing diameters, down to 25 μm. No previous work of physical flow phantom has ventured into this small scale. Overlapping phantom images acquired from clinical CT and micro-CT are used to verify the image registration fidelity.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2011
Subtitle of host publicationVisualization, Image-Guided Procedures, and Modeling
StatePublished - 2011
EventMedical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling - Lake Buena Vista, FL, United States
Duration: Feb 13 2011Feb 15 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • 3D reconstruction
  • Hybrid modalities
  • Micro-CT
  • Microvascular flow phantoms


Dive into the research topics of '3D reconstruction of microvascular flow phantoms with hybrid imaging modalities'. Together they form a unique fingerprint.

Cite this