3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors

Kaiyan Qiu, Zichen Zhao, Ghazaleh Haghiashtiani, Shuang Zhuang Guo, Mingyu He, Ruitao Su, Zhijie Zhu, Didarul B. Bhuiyan, Paari Murugan, Fanben Meng, Sung Hyun Park, Chih Chang Chu, Brenda M. Ogle, Daniel A. Saltzman, Badrinath R. Konety, Robert M. Sweet, Michael C. McAlpine

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The design and development of novel methodologies and customized materials to fabricate patient-specific 3D printed organ models with integrated sensing capabilities can yield advances in smart surgical aids for preoperative planning and rehearsal. Here, 3D printed prostate models are demonstrated with physical properties of tissue and integrated soft electronic sensors using custom-formulated polymeric inks. The models show high quantitative fidelity in static and dynamic mechanical properties, optical characteristics, and anatomical geometries to patient tissues and organs. The models offer tissue-mimicking tactile sensation and behavior and thus can be used for the prediction of organ physical behavior under deformation. The prediction results show good agreement with values obtained from simulations. The models also allow the application of surgical and diagnostic tools to their surface and inner channels. Finally, via the conformal integration of 3D printed soft electronic sensors, pressure applied to the models with surgical tools can be quantitatively measured.

Original languageEnglish (US)
Article number1700235
JournalAdvanced Materials Technologies
Volume3
Issue number3
Early online dateDec 2017
DOIs
StatePublished - Mar 2018

Keywords

  • 3D printing, organ models, 3D printed sensors, surgical aids, soft materials

PubMed: MeSH publication types

  • Journal Article

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    Qiu, K., Zhao, Z., Haghiashtiani, G., Guo, S. Z., He, M., Su, R., Zhu, Z., Bhuiyan, D. B., Murugan, P., Meng, F., Park, S. H., Chu, C. C., Ogle, B. M., Saltzman, D. A., Konety, B. R., Sweet, R. M., & McAlpine, M. C. (2018). 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors. Advanced Materials Technologies, 3(3), [1700235]. https://doi.org/10.1002/admt.201700235