3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

SWeep Imaging with Fourier Transformation (SWIFT) with gradient modulation and DC navigator retrospective gating is introduced as a 3D cine magnetic resonance imaging (MRI) method for the lung. In anesthetized normal rats, the quasi-simultaneous excitation and acquisition in SWIFT enabled extremely high sensitivity to the fast-decaying parenchymal signals (TE=∼4 μs), which are invisible with conventional MRI techniques. Respiratory motion information was extracted from DC navigator signals and the SWIFT data were reconstructed to 3D cine images with 16 respiratory phases. To test this technique's capabilities, rats exposed to > 95% O2 for 60 hours for induction of acute respiratory distress syndrome (ARDS), were imaged and compared with normal rat lungs (N=7 and 5 for ARDS and normal groups, respectively). SWIFT images showed lung tissue density differences along the gravity direction. In the cine SWIFT images, a parenchymal signal drop at the inhalation phase was consistently observed for both normal and ARDS rats due to lung inflation (i.e. decrease of the proton density), but the drop was less for ARDS rats. Depending on the respiratory phase and lung region, the lungs from the ARDS rats showed 1-24% higher parenchymal signal intensities relative to the normal rat lungs, likely due to accumulated extravascular water (EVLW). Those results demonstrate that SWIFT has high enough sensitivity for detecting the lung proton density changes due to gravity, different phases of respiration and accumulation of EVLW in the rat ARDS lungs.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Robert C. Molthen
PublisherSPIE
ISBN (Electronic)9781628415070
DOIs
StatePublished - Jan 1 2015
EventMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 24 2015Feb 26 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9417
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityOrlando
Period2/24/152/26/15

    Fingerprint

Keywords

  • Acute respiratory distress syndrome (ARDS)
  • Extravascular lung water (EVLW)
  • Gradient modulation
  • Lung
  • Magnetic resonance imaging (MRI)
  • Retrospective gating
  • Sweep imaging with Fourier transform (SWIFT)
  • Ultrashort echo time

Cite this

Kobayashi, N., Lei, J., Utecht, L., Garwood, M., Ingbar, D. H., & Bhargava, M. (2015). 3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating. In B. Gimi, & R. C. Molthen (Eds.), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging [941718] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417). SPIE. https://doi.org/10.1117/12.2081757