3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

SWeep Imaging with Fourier Transformation (SWIFT) with gradient modulation and DC navigator retrospective gating is introduced as a 3D cine magnetic resonance imaging (MRI) method for the lung. In anesthetized normal rats, the quasi-simultaneous excitation and acquisition in SWIFT enabled extremely high sensitivity to the fast-decaying parenchymal signals (TE=∼4 μs), which are invisible with conventional MRI techniques. Respiratory motion information was extracted from DC navigator signals and the SWIFT data were reconstructed to 3D cine images with 16 respiratory phases. To test this technique's capabilities, rats exposed to > 95% O2 for 60 hours for induction of acute respiratory distress syndrome (ARDS), were imaged and compared with normal rat lungs (N=7 and 5 for ARDS and normal groups, respectively). SWIFT images showed lung tissue density differences along the gravity direction. In the cine SWIFT images, a parenchymal signal drop at the inhalation phase was consistently observed for both normal and ARDS rats due to lung inflation (i.e. decrease of the proton density), but the drop was less for ARDS rats. Depending on the respiratory phase and lung region, the lungs from the ARDS rats showed 1-24% higher parenchymal signal intensities relative to the normal rat lungs, likely due to accumulated extravascular water (EVLW). Those results demonstrate that SWIFT has high enough sensitivity for detecting the lung proton density changes due to gravity, different phases of respiration and accumulation of EVLW in the rat ARDS lungs.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Robert C. Molthen
PublisherSPIE
ISBN (Electronic)9781628415070
DOIs
StatePublished - Jan 1 2015
EventMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 24 2015Feb 26 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9417
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityOrlando
Period2/24/152/26/15

Fingerprint

Cine Magnetic Resonance Imaging
Fourier transformation
Adult Respiratory Distress Syndrome
Magnetic resonance
lungs
rats
magnetic resonance
Rats
Imaging techniques
Lung
gradients
navigators
respiration
Gravitation
Protons
direct current
gravitation
Water
sensitivity
Economic Inflation

Keywords

  • Acute respiratory distress syndrome (ARDS)
  • Extravascular lung water (EVLW)
  • Gradient modulation
  • Lung
  • Magnetic resonance imaging (MRI)
  • Retrospective gating
  • Sweep imaging with Fourier transform (SWIFT)
  • Ultrashort echo time

Cite this

Kobayashi, N., Lei, J., Utecht, L., Garwood, M., Ingbar, D. H., & Bhargava, M. (2015). 3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating. In B. Gimi, & R. C. Molthen (Eds.), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging [941718] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417). SPIE. https://doi.org/10.1117/12.2081757

3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating. / Kobayashi, Naoharu; Lei, Jianxun; Utecht, Lynn; Garwood, Michael; Ingbar, David H; Bhargava, Maneesh.

Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Barjor Gimi; Robert C. Molthen. SPIE, 2015. 941718 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9417).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kobayashi, N, Lei, J, Utecht, L, Garwood, M, Ingbar, DH & Bhargava, M 2015, 3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating. in B Gimi & RC Molthen (eds), Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging., 941718, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9417, SPIE, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, United States, 2/24/15. https://doi.org/10.1117/12.2081757
Kobayashi N, Lei J, Utecht L, Garwood M, Ingbar DH, Bhargava M. 3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating. In Gimi B, Molthen RC, editors, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE. 2015. 941718. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2081757
Kobayashi, Naoharu ; Lei, Jianxun ; Utecht, Lynn ; Garwood, Michael ; Ingbar, David H ; Bhargava, Maneesh. / 3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating. Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Barjor Gimi ; Robert C. Molthen. SPIE, 2015. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
@inproceedings{31215ee98e724444a3fe4eda62bc7cf4,
title = "3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating",
abstract = "SWeep Imaging with Fourier Transformation (SWIFT) with gradient modulation and DC navigator retrospective gating is introduced as a 3D cine magnetic resonance imaging (MRI) method for the lung. In anesthetized normal rats, the quasi-simultaneous excitation and acquisition in SWIFT enabled extremely high sensitivity to the fast-decaying parenchymal signals (TE=∼4 μs), which are invisible with conventional MRI techniques. Respiratory motion information was extracted from DC navigator signals and the SWIFT data were reconstructed to 3D cine images with 16 respiratory phases. To test this technique's capabilities, rats exposed to > 95{\%} O2 for 60 hours for induction of acute respiratory distress syndrome (ARDS), were imaged and compared with normal rat lungs (N=7 and 5 for ARDS and normal groups, respectively). SWIFT images showed lung tissue density differences along the gravity direction. In the cine SWIFT images, a parenchymal signal drop at the inhalation phase was consistently observed for both normal and ARDS rats due to lung inflation (i.e. decrease of the proton density), but the drop was less for ARDS rats. Depending on the respiratory phase and lung region, the lungs from the ARDS rats showed 1-24{\%} higher parenchymal signal intensities relative to the normal rat lungs, likely due to accumulated extravascular water (EVLW). Those results demonstrate that SWIFT has high enough sensitivity for detecting the lung proton density changes due to gravity, different phases of respiration and accumulation of EVLW in the rat ARDS lungs.",
keywords = "Acute respiratory distress syndrome (ARDS), Extravascular lung water (EVLW), Gradient modulation, Lung, Magnetic resonance imaging (MRI), Retrospective gating, Sweep imaging with Fourier transform (SWIFT), Ultrashort echo time",
author = "Naoharu Kobayashi and Jianxun Lei and Lynn Utecht and Michael Garwood and Ingbar, {David H} and Maneesh Bhargava",
year = "2015",
month = "1",
day = "1",
doi = "10.1117/12.2081757",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Barjor Gimi and Molthen, {Robert C.}",
booktitle = "Medical Imaging 2015",
address = "United States",

}

TY - GEN

T1 - 3D cine magnetic resonance imaging of rat lung ARDS using gradient-modulated SWIFT with retrospective respiratory gating

AU - Kobayashi, Naoharu

AU - Lei, Jianxun

AU - Utecht, Lynn

AU - Garwood, Michael

AU - Ingbar, David H

AU - Bhargava, Maneesh

PY - 2015/1/1

Y1 - 2015/1/1

N2 - SWeep Imaging with Fourier Transformation (SWIFT) with gradient modulation and DC navigator retrospective gating is introduced as a 3D cine magnetic resonance imaging (MRI) method for the lung. In anesthetized normal rats, the quasi-simultaneous excitation and acquisition in SWIFT enabled extremely high sensitivity to the fast-decaying parenchymal signals (TE=∼4 μs), which are invisible with conventional MRI techniques. Respiratory motion information was extracted from DC navigator signals and the SWIFT data were reconstructed to 3D cine images with 16 respiratory phases. To test this technique's capabilities, rats exposed to > 95% O2 for 60 hours for induction of acute respiratory distress syndrome (ARDS), were imaged and compared with normal rat lungs (N=7 and 5 for ARDS and normal groups, respectively). SWIFT images showed lung tissue density differences along the gravity direction. In the cine SWIFT images, a parenchymal signal drop at the inhalation phase was consistently observed for both normal and ARDS rats due to lung inflation (i.e. decrease of the proton density), but the drop was less for ARDS rats. Depending on the respiratory phase and lung region, the lungs from the ARDS rats showed 1-24% higher parenchymal signal intensities relative to the normal rat lungs, likely due to accumulated extravascular water (EVLW). Those results demonstrate that SWIFT has high enough sensitivity for detecting the lung proton density changes due to gravity, different phases of respiration and accumulation of EVLW in the rat ARDS lungs.

AB - SWeep Imaging with Fourier Transformation (SWIFT) with gradient modulation and DC navigator retrospective gating is introduced as a 3D cine magnetic resonance imaging (MRI) method for the lung. In anesthetized normal rats, the quasi-simultaneous excitation and acquisition in SWIFT enabled extremely high sensitivity to the fast-decaying parenchymal signals (TE=∼4 μs), which are invisible with conventional MRI techniques. Respiratory motion information was extracted from DC navigator signals and the SWIFT data were reconstructed to 3D cine images with 16 respiratory phases. To test this technique's capabilities, rats exposed to > 95% O2 for 60 hours for induction of acute respiratory distress syndrome (ARDS), were imaged and compared with normal rat lungs (N=7 and 5 for ARDS and normal groups, respectively). SWIFT images showed lung tissue density differences along the gravity direction. In the cine SWIFT images, a parenchymal signal drop at the inhalation phase was consistently observed for both normal and ARDS rats due to lung inflation (i.e. decrease of the proton density), but the drop was less for ARDS rats. Depending on the respiratory phase and lung region, the lungs from the ARDS rats showed 1-24% higher parenchymal signal intensities relative to the normal rat lungs, likely due to accumulated extravascular water (EVLW). Those results demonstrate that SWIFT has high enough sensitivity for detecting the lung proton density changes due to gravity, different phases of respiration and accumulation of EVLW in the rat ARDS lungs.

KW - Acute respiratory distress syndrome (ARDS)

KW - Extravascular lung water (EVLW)

KW - Gradient modulation

KW - Lung

KW - Magnetic resonance imaging (MRI)

KW - Retrospective gating

KW - Sweep imaging with Fourier transform (SWIFT)

KW - Ultrashort echo time

UR - http://www.scopus.com/inward/record.url?scp=84943413008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943413008&partnerID=8YFLogxK

U2 - 10.1117/12.2081757

DO - 10.1117/12.2081757

M3 - Conference contribution

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2015

A2 - Gimi, Barjor

A2 - Molthen, Robert C.

PB - SPIE

ER -