3-D localization of Diabetic Macular Edema using OCT thickness maps

Sohini Roychowdhury; Dara Koozekanani; Michael Reinsbach; Keshab K Parhi

doi:10.1109/EMBC.2015.7319354

3-D localization of Diabetic Macular Edema using OCT thickness maps

Sohini Roychowdhury
, Dara Koozekanani
, Michael Reinsbach
, Keshab K Parhi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

This paper presents a novel automated system that segments 3-D thickness maps of sub-retinal layers from healthy and abnormal OCT image stacks with Diabetic Macular Edema (DME). These automated thickness maps are well correlated (r > 0.7) with the manually segmented thickness maps. The thickness maps demonstrate highly irregular regions in the inner and outer nuclear layers for patients with DME when compared to the healthy images. The combined area of irregularity in the inner and outer nuclear layers can thereby be extracted as a novel metric with correlation r = 0.99 to track the severity of DME. No other existing automated algorithm has extracted inner sub-retinal layer thickness maps from OCT image stacks of DME patients. The proposed system is fast and robust in locating the sub-retinal changes caused by DME in the 3-D sub-retinal micro-structure.

Original language	English (US)
Title of host publication	2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4334-4337
Number of pages	4
ISBN (Electronic)	9781424492718
DOIs	https://doi.org/10.1109/EMBC.2015.7319354
State	Published - Nov 4 2015
Event	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy Duration: Aug 25 2015 → Aug 29 2015

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2015-November
ISSN (Print)	1557-170X

Other

Other	37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Country/Territory	Italy
City	Milan
Period	8/25/15 → 8/29/15

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

Keywords

denoising
segmentation
thickness map

Publisher link

10.1109/EMBC.2015.7319354

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Roychowdhury, S., Koozekanani, D., Reinsbach, M., & Parhi, K. K. (2015). 3-D localization of Diabetic Macular Edema using OCT thickness maps. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 (pp. 4334-4337). Article 7319354 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2015-November). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319354

3-D localization of Diabetic Macular Edema using OCT thickness maps. / Roychowdhury, Sohini; Koozekanani, Dara; Reinsbach, Michael et al.
2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. p. 4334-4337 7319354 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2015-November).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Roychowdhury, S, Koozekanani, D, Reinsbach, M & Parhi, KK 2015, 3-D localization of Diabetic Macular Edema using OCT thickness maps. in 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015., 7319354, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2015-November, Institute of Electrical and Electronics Engineers Inc., pp. 4334-4337, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7319354

Roychowdhury S, Koozekanani D, Reinsbach M, Parhi KK. 3-D localization of Diabetic Macular Edema using OCT thickness maps. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc. 2015. p. 4334-4337. 7319354. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2015.7319354

Roychowdhury, Sohini ; Koozekanani, Dara ; Reinsbach, Michael et al. / 3-D localization of Diabetic Macular Edema using OCT thickness maps. 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 4334-4337 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "3-D localization of Diabetic Macular Edema using OCT thickness maps",

abstract = "This paper presents a novel automated system that segments 3-D thickness maps of sub-retinal layers from healthy and abnormal OCT image stacks with Diabetic Macular Edema (DME). These automated thickness maps are well correlated (r > 0.7) with the manually segmented thickness maps. The thickness maps demonstrate highly irregular regions in the inner and outer nuclear layers for patients with DME when compared to the healthy images. The combined area of irregularity in the inner and outer nuclear layers can thereby be extracted as a novel metric with correlation r = 0.99 to track the severity of DME. No other existing automated algorithm has extracted inner sub-retinal layer thickness maps from OCT image stacks of DME patients. The proposed system is fast and robust in locating the sub-retinal changes caused by DME in the 3-D sub-retinal micro-structure.",

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author = "Sohini Roychowdhury and Dara Koozekanani and Michael Reinsbach and Parhi, \{Keshab K\}",

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N2 - This paper presents a novel automated system that segments 3-D thickness maps of sub-retinal layers from healthy and abnormal OCT image stacks with Diabetic Macular Edema (DME). These automated thickness maps are well correlated (r > 0.7) with the manually segmented thickness maps. The thickness maps demonstrate highly irregular regions in the inner and outer nuclear layers for patients with DME when compared to the healthy images. The combined area of irregularity in the inner and outer nuclear layers can thereby be extracted as a novel metric with correlation r = 0.99 to track the severity of DME. No other existing automated algorithm has extracted inner sub-retinal layer thickness maps from OCT image stacks of DME patients. The proposed system is fast and robust in locating the sub-retinal changes caused by DME in the 3-D sub-retinal micro-structure.

AB - This paper presents a novel automated system that segments 3-D thickness maps of sub-retinal layers from healthy and abnormal OCT image stacks with Diabetic Macular Edema (DME). These automated thickness maps are well correlated (r > 0.7) with the manually segmented thickness maps. The thickness maps demonstrate highly irregular regions in the inner and outer nuclear layers for patients with DME when compared to the healthy images. The combined area of irregularity in the inner and outer nuclear layers can thereby be extracted as a novel metric with correlation r = 0.99 to track the severity of DME. No other existing automated algorithm has extracted inner sub-retinal layer thickness maps from OCT image stacks of DME patients. The proposed system is fast and robust in locating the sub-retinal changes caused by DME in the 3-D sub-retinal micro-structure.

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3-D localization of Diabetic Macular Edema using OCT thickness maps

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