3-(1′-hydroxyethyl)-2-azetidinones from 3-hydroxybutyrates and n-arylaldimines

Gunda I. Georg, Harpal S. Gill, Cathy Gerhardt

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Dianion imine addition, cyclisation reaction between ethyl-3-hydroxybutyrate and aldimines generates β-lactams with the hydroxyethyl sidechain of thienamycin and related β-lactam antibiotics in place. The effects of the N-arylaldimine and the reaction conditions on the stereochemistry of the resulting products are examined.

Original languageEnglish (US)
Pages (from-to)3903-3906
Number of pages4
JournalTetrahedron Letters
Issue number33
StatePublished - 1985

Bibliographical note

Funding Information:
a grant from the National Institutes of Health.


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