24-h blood pressure profile in patients with sleep apnea syndrom: The effect of therapy

J. Siegelova, Z. Kadanka, M. Moran, B. Fiser, P. Homolka, P. Dobsak, J. Dusek, G. Cornelissen, F. Halberg

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1 Scopus citations


Investigation of circadian variation of blood pressure in patients with sleep apnea syndrom (SAS) before and after the therapy was the aim of the present study. Sixteen patients before treatment (mean apnea + hypopnea index was 52.8 ± 22.7) and 11 patients after one-year treatment with continuous positive airway pressure (CPAP) were examined by ambulatory blood pressure monitoring. The results were evaluated by means of cosinor analysis. The 24-hour blood pressure profile was not different before and after one-year CPAP therapy. The therapy increased 24-hour amplitude of systolic blood pressure from 4.9 ± 3.3 (mean + confidence interval) to 7.2 ± 3.9 mm Hg (p < 0.05) and changed acrophase from -235 to -327 degree (p < 0.05) Diastolic blood pressure amplitude remained low in both groups (without treatment: 2.5 ± 2.3, after treatment: 1.0 ± 2.8 mm He). We can conclude that one-year long CPAP therapy of SAS doesn't normalize the circadian variation of blood pressure.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Issue number4
StatePublished - Dec 1 1998


  • 24-h blood pressure
  • Sleep apnea syndrom
  • Therapy effect


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