2,4-Di-tert-butylphenol from sweet potato protects against oxidative stress in PC12 cells and in mice

Soo Jung Choi, Jae Kyeom Kim, Hye Kyung Kim, Keith Harris, Chang Ju Kim, Gwi Gun Park, Cheung Seog Park, Dong Hoon Shin

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


In this study, the protective effect of sweet potato extract against hydrogen peroxide-induced oxidative stress and cytotoxicity on the pheochromocytoma cell line (PC12) was investigated. The active component of the sweet potato extract was purified and determined to be 2,4-di-tert-butylphenol. The antioxidant capacity of 2,4-di-tert-butylphenol was measured by using 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical. To examine the effects of 2,4-di-tert-butylphenol on amyloid-beta peptide (Aβ1-42)-induced learning and memory impairment in mice, in vivo behavioral tests were performed. Administration of 2,4-di-tert-butylphenol increased alternation behavior in mice injected with Aβ1-42. These results suggest that sweet potato extract could be protective against Aβ-induced neurotoxicity, possibly due to the antioxidative capacity of its constituent, 2,4-di-tert-butylphenol.

Original languageEnglish (US)
Pages (from-to)977-983
Number of pages7
JournalJournal of Medicinal Food
Issue number11
StatePublished - Nov 1 2013


  • Alzheimer's disease
  • Amyloid beta peptide
  • Oxidative stress
  • PC12 cells


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