2,2,2-Trichloroethyl aryldiazoacetates as robust reagents for the enantioselective C-H functionalization of methyl ethers

David M Guptill, Huw M.L. Davies

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A new class of reagents is described for C-H functionalization by means of C-H insertion using donor/acceptor-substituted rhodium(II) carbene intermediates. The 2,2,2-trichloroethyl aryl and heteroaryl diazoacetates, together with the dirhodium triarylcyclopropane carboxylate catalyst Rh2(R-BPCP)4, enabled the enantioselective intermolecular C-H functionalization of a range of methyl ethers with high levels of site selectivity and enantioselectivity.

Original languageEnglish (US)
Pages (from-to)17718-17721
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number51
DOIs
StatePublished - Dec 24 2014

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