TY - JOUR
T1 - 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke
T2 - A Guideline From the American Heart Association/American Stroke Association
AU - Zachrison, Mori
AU - Zachrison, Z.
AU - Zachrison, Kori S.
AU - Ansari, S.
AU - Ansari, A.
AU - Ansari, Sameer A.
AU - Ansari, S.
AU - Snsari, S.
AU - Pnsari, P.
AU - Ishida, Koto
AU - Jadhav, Ashutosh P.
AU - Madsen, E.
AU - Madsen, Tracy E.
AU - Mistry, Eva A.
AU - Park, Soojin
AU - Saiz, S.
AU - Saiz, Tania
AU - Saiz, Aania
AU - Schwartzberg, Dana
AU - Schwartzberg, S.
AU - Schwartzberg, Vana
AU - Schwartzberg, M.
AU - Tjoumakaris, Stavropoula
AU - Tjoumakaris, T.
AU - Vjoumakaris, V.
AU - Leira, Enrique C.
AU - Broderick, Joseph P.
AU - Arauz, Antonio
AU - Ardelt, Agnieszka
AU - Bahouth, Mona
AU - Caulfield, Anna Finley
AU - Derdeyn, Colin P.
AU - Dylla, Layne
AU - Frankel, Michael
AU - Fullerton, Heather J.
AU - Guerrero, Waldo R.
AU - Jauch, Edward C.
AU - Kicielinski, Kimberly P.
AU - Labram, Yvonne
AU - Lyden, Patrick
AU - Marsh, Elisabeth B.
AU - Meurer, William J.
AU - Mocco, J.
AU - Pandey, Aditya
AU - Rabinstein, Alejandro A.
AU - Rapp, Karen
AU - Richards, Christopher T.
AU - Rocha, Marcelo
AU - Royan, Regina
AU - Samaniego, Edgar A.
AU - Sangha, Navdeep S.
AU - Schirmer, Clemens
AU - Simpkins, Alexis N.
AU - Streib, Christopher
AU - Tirschwell, David
AU - Zink, Elizabeth
N1 - Publisher Copyright:
© 2026 American Heart Association, Inc.
PY - 2026/1
Y1 - 2026/1
N2 - AIM: – The “2026 Guideline for the Early Management of Patients With AIS” replaces the “2018 Guidelines for the Early Management of Patients With AIS” and the 2019 update to reflect recent advances in evidence. This updated guideline is intended to provide a comprehensive, up-to-date, evidence-based set of recommendations, advising management from prehospital evaluation through acute treatment and early in-hospital management of complications and initiation of early secondary prevention measures. The intended audience includes prehospital care professionals, physicians, allied health professionals, and hospital administrators. METHODS: – A search for literature derived from research principally involving human subjects, published in English since the last AIS guideline in 2018 and the 2019 update, and indexed in MEDLINE, PubMed, Cochrane Library, and other selected databases relevant to this guideline, was conducted between September and December 2024. Additional high impact studies and articles published through March 2025 were added later, where appropriate. STRUCTURE: – This guideline represents the most current and comprehensive evidence available in AIS care. Key updates include the incorporation of new evidence related to thrombolytic choice and eligibility, determination of eligibility for endovascular thrombectomy, and management of hyperglycemia and dysphagia; a focused consideration of the pediatric population; and modification of the approach to thrombolysis contraindications. Although this guideline reflects significant advances, it also highlights gaps in knowledge and underscores the urgent need for continued research to further refine and improve treatment strategies.
AB - AIM: – The “2026 Guideline for the Early Management of Patients With AIS” replaces the “2018 Guidelines for the Early Management of Patients With AIS” and the 2019 update to reflect recent advances in evidence. This updated guideline is intended to provide a comprehensive, up-to-date, evidence-based set of recommendations, advising management from prehospital evaluation through acute treatment and early in-hospital management of complications and initiation of early secondary prevention measures. The intended audience includes prehospital care professionals, physicians, allied health professionals, and hospital administrators. METHODS: – A search for literature derived from research principally involving human subjects, published in English since the last AIS guideline in 2018 and the 2019 update, and indexed in MEDLINE, PubMed, Cochrane Library, and other selected databases relevant to this guideline, was conducted between September and December 2024. Additional high impact studies and articles published through March 2025 were added later, where appropriate. STRUCTURE: – This guideline represents the most current and comprehensive evidence available in AIS care. Key updates include the incorporation of new evidence related to thrombolytic choice and eligibility, determination of eligibility for endovascular thrombectomy, and management of hyperglycemia and dysphagia; a focused consideration of the pediatric population; and modification of the approach to thrombolysis contraindications. Although this guideline reflects significant advances, it also highlights gaps in knowledge and underscores the urgent need for continued research to further refine and improve treatment strategies.
KW - AHA Scientific Statements
KW - endovascular procedures
KW - guideline
KW - ischemic stroke
KW - stroke
KW - thrombolytic therapy
UR - https://www.scopus.com/pages/publications/105030024300
UR - https://www.scopus.com/pages/publications/105030024300#tab=citedBy
U2 - 10.1161/str.0000000000000513
DO - 10.1161/str.0000000000000513
M3 - Review article
C2 - 41582814
AN - SCOPUS:105030024300
SN - 0039-2499
JO - Stroke
JF - Stroke
ER -
SDG 3 Good Health and Well-being