2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People

Sandra R. Arnold; Andrej Spec; John W. Baddley; Peter Pappas; Robert J. Lentz; Joshua Wolf; Carol A. Kauffman; Monica I. Ardura; Nevert Badreldin; Nathan C. Bahr; Karen Bloch; Rachel A. Miller; Satish Mocherla; Michael Saccente; Ilan Schwartz; Kayla R. Stover; Nathan P. Wiederhold; Jennifer Loveless

doi:10.1093/cid/ciaf256

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People

Sandra R. Arnold
, Andrej Spec
, John W. Baddley
, Peter Pappas
, Robert J. Lentz
, Joshua Wolf
, Carol A. Kauffman
, Monica I. Ardura
, Nevert Badreldin
, Nathan C. Bahr
, Karen Bloch
, Rachel A. Miller
, Satish Mocherla
, Michael Saccente
, Ilan Schwartz
, Kayla R. Stover
, Nathan P. Wiederhold
, Jennifer Loveless

Medicine - Infectious Disease and International Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

As the first part of an update to the clinical practice guideline on the management of histoplasmosis in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, we present 4 updated recommendations. These recommendations span treatment of asymptomatic Histoplasma pulmonary nodules (histoplasmomas), mild acute pulmonary histoplasmosis, and moderate acute pulmonary histoplasmosis. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.

Original language	English (US)
Pages (from-to)	i27-i32
Journal	Clinical Infectious Diseases
Volume	81
DOIs	https://doi.org/10.1093/cid/ciaf256
State	Published - Oct 15 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.

Keywords

asymptomatic pulmonary nodules
guideline
histoplasmoma
histoplasmosis

PubMed: MeSH publication types

Journal Article
Practice Guideline
Research Support, Non-U.S. Gov't

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10.1093/cid/ciaf256

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Arnold, S. R., Spec, A., Baddley, J. W., Pappas, P., Lentz, R. J., Wolf, J., Kauffman, C. A., Ardura, M. I., Badreldin, N., Bahr, N. C., Bloch, K., Miller, R. A., Mocherla, S., Saccente, M., Schwartz, I., Stover, K. R., Wiederhold, N. P., & Loveless, J. (2025). 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People. Clinical Infectious Diseases, 81, i27-i32. https://doi.org/10.1093/cid/ciaf256

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People. / Arnold, Sandra R.; Spec, Andrej; Baddley, John W. et al.
In: Clinical Infectious Diseases, Vol. 81, 15.10.2025, p. i27-i32.

Research output: Contribution to journal › Article › peer-review

Arnold, SR, Spec, A, Baddley, JW, Pappas, P, Lentz, RJ, Wolf, J, Kauffman, CA, Ardura, MI, Badreldin, N, Bahr, NC, Bloch, K, Miller, RA, Mocherla, S, Saccente, M, Schwartz, I, Stover, KR, Wiederhold, NP & Loveless, J 2025, '2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People', Clinical Infectious Diseases, vol. 81, pp. i27-i32. https://doi.org/10.1093/cid/ciaf256

Arnold SR, Spec A, Baddley JW, Pappas P, Lentz RJ, Wolf J et al. 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People. Clinical Infectious Diseases. 2025 Oct 15;81:i27-i32. doi: 10.1093/cid/ciaf256

Arnold, Sandra R. ; Spec, Andrej ; Baddley, John W. et al. / 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis : Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People. In: Clinical Infectious Diseases. 2025 ; Vol. 81. pp. i27-i32.

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abstract = "As the first part of an update to the clinical practice guideline on the management of histoplasmosis in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, we present 4 updated recommendations. These recommendations span treatment of asymptomatic Histoplasma pulmonary nodules (histoplasmomas), mild acute pulmonary histoplasmosis, and moderate acute pulmonary histoplasmosis. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.",

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2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

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