20 years or more of follow-up of living kidney donors

J. S. Najarian, L. E. McHugh, A. J. Matas, B. M. Chavers

Research output: Contribution to journalArticle

504 Citations (Scopus)

Abstract

The perioperative and long-term risks for living kidney donors are of concern. We have studied donors at the University of Minnesota 20 years or more (mean 23·7) after donation by comparing renal function, blood pressure, and proteinuria in donors with siblings. In 57 donors (mean age 61 [SE 1]), mean serum creatinine is 1·1 (0·01) mg/dl, blood urea nitrogen 17 (0·5) mg/dl, creatinine clearance 82 (2) ml/min, and blood pressure 134 (2)/80 (1) mm Hg. 32% of the donors are taking antihypertensive drugs and 23% have proteinuria. The 65 siblings (mean age 58 [1·3]) do not significantly differ from the donors in any of these variables: 1·1 (0·03) mg/dl, 17 (1·2) mg/dl, 89 (3·3) ml/min, and 130 (3)/80 (1·5) mm Hg, respectively. 44% of the siblings are taking antihypertensives and 22% have proteinuria. To assess perioperative mortality, we surveyed all members of the American Society of Transplant Surgeons about donor mortality at their institutions. We documented 17 perioperative deaths in the USA and Canada after living donation, and estimate mortality to be 0·03%. We conclude that perioperative mortality in the USA and Canada after living-donor nephrectomy is low. In long-term follow-up of our living donors, we found no evidence of progressive renal deterioration or other serious disorders.

Original languageEnglish (US)
Pages (from-to)807-810
Number of pages4
JournalThe Lancet
Volume340
Issue number8823
DOIs
StatePublished - Oct 3 1992

Fingerprint

Living Donors
Tissue Donors
Kidney
Proteinuria
Siblings
Mortality
Antihypertensive Agents
Canada
Creatinine
Blood Pressure
Blood Urea Nitrogen
Nephrectomy
Serum

Cite this

20 years or more of follow-up of living kidney donors. / Najarian, J. S.; McHugh, L. E.; Matas, A. J.; Chavers, B. M.

In: The Lancet, Vol. 340, No. 8823, 03.10.1992, p. 807-810.

Research output: Contribution to journalArticle

Najarian, J. S. ; McHugh, L. E. ; Matas, A. J. ; Chavers, B. M. / 20 years or more of follow-up of living kidney donors. In: The Lancet. 1992 ; Vol. 340, No. 8823. pp. 807-810.
@article{b34adb7139e24cd1b581b0623d8ec6ef,
title = "20 years or more of follow-up of living kidney donors",
abstract = "The perioperative and long-term risks for living kidney donors are of concern. We have studied donors at the University of Minnesota 20 years or more (mean 23·7) after donation by comparing renal function, blood pressure, and proteinuria in donors with siblings. In 57 donors (mean age 61 [SE 1]), mean serum creatinine is 1·1 (0·01) mg/dl, blood urea nitrogen 17 (0·5) mg/dl, creatinine clearance 82 (2) ml/min, and blood pressure 134 (2)/80 (1) mm Hg. 32{\%} of the donors are taking antihypertensive drugs and 23{\%} have proteinuria. The 65 siblings (mean age 58 [1·3]) do not significantly differ from the donors in any of these variables: 1·1 (0·03) mg/dl, 17 (1·2) mg/dl, 89 (3·3) ml/min, and 130 (3)/80 (1·5) mm Hg, respectively. 44{\%} of the siblings are taking antihypertensives and 22{\%} have proteinuria. To assess perioperative mortality, we surveyed all members of the American Society of Transplant Surgeons about donor mortality at their institutions. We documented 17 perioperative deaths in the USA and Canada after living donation, and estimate mortality to be 0·03{\%}. We conclude that perioperative mortality in the USA and Canada after living-donor nephrectomy is low. In long-term follow-up of our living donors, we found no evidence of progressive renal deterioration or other serious disorders.",
author = "Najarian, {J. S.} and McHugh, {L. E.} and Matas, {A. J.} and Chavers, {B. M.}",
year = "1992",
month = "10",
day = "3",
doi = "10.1016/0140-6736(92)92683-7",
language = "English (US)",
volume = "340",
pages = "807--810",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8823",

}

TY - JOUR

T1 - 20 years or more of follow-up of living kidney donors

AU - Najarian, J. S.

AU - McHugh, L. E.

AU - Matas, A. J.

AU - Chavers, B. M.

PY - 1992/10/3

Y1 - 1992/10/3

N2 - The perioperative and long-term risks for living kidney donors are of concern. We have studied donors at the University of Minnesota 20 years or more (mean 23·7) after donation by comparing renal function, blood pressure, and proteinuria in donors with siblings. In 57 donors (mean age 61 [SE 1]), mean serum creatinine is 1·1 (0·01) mg/dl, blood urea nitrogen 17 (0·5) mg/dl, creatinine clearance 82 (2) ml/min, and blood pressure 134 (2)/80 (1) mm Hg. 32% of the donors are taking antihypertensive drugs and 23% have proteinuria. The 65 siblings (mean age 58 [1·3]) do not significantly differ from the donors in any of these variables: 1·1 (0·03) mg/dl, 17 (1·2) mg/dl, 89 (3·3) ml/min, and 130 (3)/80 (1·5) mm Hg, respectively. 44% of the siblings are taking antihypertensives and 22% have proteinuria. To assess perioperative mortality, we surveyed all members of the American Society of Transplant Surgeons about donor mortality at their institutions. We documented 17 perioperative deaths in the USA and Canada after living donation, and estimate mortality to be 0·03%. We conclude that perioperative mortality in the USA and Canada after living-donor nephrectomy is low. In long-term follow-up of our living donors, we found no evidence of progressive renal deterioration or other serious disorders.

AB - The perioperative and long-term risks for living kidney donors are of concern. We have studied donors at the University of Minnesota 20 years or more (mean 23·7) after donation by comparing renal function, blood pressure, and proteinuria in donors with siblings. In 57 donors (mean age 61 [SE 1]), mean serum creatinine is 1·1 (0·01) mg/dl, blood urea nitrogen 17 (0·5) mg/dl, creatinine clearance 82 (2) ml/min, and blood pressure 134 (2)/80 (1) mm Hg. 32% of the donors are taking antihypertensive drugs and 23% have proteinuria. The 65 siblings (mean age 58 [1·3]) do not significantly differ from the donors in any of these variables: 1·1 (0·03) mg/dl, 17 (1·2) mg/dl, 89 (3·3) ml/min, and 130 (3)/80 (1·5) mm Hg, respectively. 44% of the siblings are taking antihypertensives and 22% have proteinuria. To assess perioperative mortality, we surveyed all members of the American Society of Transplant Surgeons about donor mortality at their institutions. We documented 17 perioperative deaths in the USA and Canada after living donation, and estimate mortality to be 0·03%. We conclude that perioperative mortality in the USA and Canada after living-donor nephrectomy is low. In long-term follow-up of our living donors, we found no evidence of progressive renal deterioration or other serious disorders.

UR - http://www.scopus.com/inward/record.url?scp=0026674581&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026674581&partnerID=8YFLogxK

U2 - 10.1016/0140-6736(92)92683-7

DO - 10.1016/0140-6736(92)92683-7

M3 - Article

C2 - 1357243

AN - SCOPUS:0026674581

VL - 340

SP - 807

EP - 810

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8823

ER -