2′-O methylation of the viral mRNA cap by West Nile virus evades Ifit1-dependent and -independent mechanisms of host restriction in vivo

Keyphrases

• West Nile Virus 100%
• Host Restriction 100%
• Viral mRNA 100%
• 2′-O-methylation 100%
• Evade 100%
• Central Nervous System 66%
• Methyltransferase Activity 66%
• 2'-O-methyltransferase 66%
• Gene Expression 33%
• Antiviral Activity 33%
• Virus 33%
• CD8+ T Cells 33%
• Blood-brain Barrier 33%
• Attenuation 33%
• Type-specific 33%
• Coronavirus 33%
• Lethality 33%
• Neuronal Death 33%
• Interferon-α (IFN-α) 33%
• Cell-mediated 33%
• Wild Mice 33%
• Pregenomic RNA (pgRNA) 33%
• Peripheral Tissues 33%
• Virulent Strain 33%
• Effector Proteins 33%
• Specific Difference 33%
• Flavivirus 33%
• Virus Entry 33%
• Viral mutant 33%
• Infectivity Assay 33%
• Human Brain Microvascular Endothelial Cells (HBMEC) 33%
• Marginal Effects 33%
• MRNA Cap 33%
• Poxvirus 33%
• Intracranial Infection 33%
• Primary Macrophages 33%
• Ex Vivo Infection 33%
• LD50 Value 33%
• Subcutaneous Infection 33%
• Viral Evasion 33%
• Cell-intrinsic 33%
• Innate Immune Effectors 33%
• NS5 Gene 33%

Immunology and Microbiology

• West Nile Virus 100%
• Methylation 100%
• Infection 100%
• Central Nervous System 33%
• Wild Type 33%
• Replication 33%
• Macrophage 16%
• Cytotoxic T-Cell 16%
• Virus 16%
• Interferon Type I 16%
• Viral Entry 16%
• Gene Expression 16%
• Blood Brain Barrier 16%
• Wild Type Mouse 16%
• Flavivirus 16%
• Coronavirus 16%
• Ribonucleic Acid 16%
• LD50 16%