2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography in characterization of solid renal masses

Rakesh Kumar, Anil Chauhan, Paras Lakhani, Yan Xiu, Hongming Zhuang, Abass Alavi

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The present study was aimed to evaluate the ability of 2-deoxy-2-[F-18]fluoro-d-glucose (FDG)-positron emission tomography (PET) in characterization of solid renal masses visualized by computed tomography (CT)/magnetic resonance imaging (MRI) in patients with suspected or known malignancies. Methods: Twenty-eight solid renal masses (20 unilateral and four bilateral, Size ranges, 1.0-8.4 cm) were evaluated in 24 patients. The results were correlated with histopathology in 15 patients, and clinical follow-up and conventional imaging in all patients. Results: Of the 28 solid renal masses, 10 were primary (nine malignant, one benign) and 18 were metastatic renal tumors. FDG-PET accurately depicted 23 of 27 (85%) malignant renal masses. Of the 10 primary renal tumors, FDG-PET was true positive in eight of nine (89%), true negative in one and false negative in one. The maximum and average standardized uptake values (SUVs) for FDG positive primary renal malignant tumors were 7.9 ± 4.9 and 6.0 ± 3.6, respectively. In addition to the characterization of primary tumors, FDG-PET was valuable in primary staging and altered treatment in 30% of patients (three of 10). Of the 18 metastatic renal masses, FDG-PET was positive in 15 (83%) masses. The maximum and average SUVs of metastatic renal masses were 6.1 ± 3.4 and 4.7 ± 2.8, respectively. There was no significant difference in maximum and average SUVs between primary and metastatic renal masses (p = 0.3 and p = 0.3). Conclusion: Despite the physiological excretion of FDG by the kidneys, FDG-PET can be employed effectively in characterization of solid renal masses in patients with suspected or known malignancies. We propose that FDG-PET could be useful as a complimentary modality to conventional imaging in these patients.

Original languageEnglish (US)
Pages (from-to)431-439
Number of pages9
JournalMolecular Imaging and Biology
Issue number6
StatePublished - Nov 2005
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgment. This research was supported in part by UICC (International Union Against Cancer) Geneva, Switzerland under ACSBI fellowship.

Copyright 2008 Elsevier B.V., All rights reserved.


  • F18-FDG-PET
  • Renal cancer
  • Renal masses
  • Renal metastatic masses


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