Abstract
Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4- phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 182-185 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 211 |
| Issue number | 4478 |
| DOIs | |
| State | Published - 1981 |