2-Amino-4-phosphonobutyric acid: A new pharmacological tool for retina research

Malcolm M. Slaughter, Robert F. Miller

Research output: Contribution to journalArticlepeer-review

686 Scopus citations


Information processing in the vertebrate retina occurs in two separate channels known as ON and OFF channels. When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge. 2-Amino-4- phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
Issue number4478
StatePublished - 1981


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