2, 8-dihydroxyadenine urolithiasis: Report of a case first diagnosed after renal transplant

Daniel Glicklich, Harry E. Gruber, Arthur J. Matast, Vivian A. Tellist, Gattu Karwat, Kim Finley, Carol Salem, Robert Soberman, J. Edwin Seegmiller

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Abstract

We report a case of homozygous adenine phosphoribosyl transferase (APRT) deficiency associated with 2, 8-dihydroxyadenine stones recurrent in a patient with a renal transplant. The disease was diagnosed 23 years after the initial episode of renal colic. At that time the disease was unknown. Our patient is only the second case of this disorder reported from the United States. Correct diagnosis is important because long-term maintenance with allopurinol and a low purine diet can effectively prevent stone formation and renal failure.

Original languageEnglish (US)
Pages (from-to)785-793
Number of pages9
JournalQJM
Volume69
Issue number1
DOIs
StatePublished - Oct 1988

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    Glicklich, D., Gruber, H. E., Matast, A. J., Tellist, V. A., Karwat, G., Finley, K., Salem, C., Soberman, R., & Seegmiller, J. E. (1988). 2, 8-dihydroxyadenine urolithiasis: Report of a case first diagnosed after renal transplant. QJM, 69(1), 785-793. https://doi.org/10.1093/oxfordjournals.qjmed.a068245