17β Estradiol-induced increase in brain dopamine D-2 receptor: Antagonism by MIF-1

G. Rajakumar, P. Chiu, S. Chiu, R. L. Johnson, R. K. Mishra

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17β-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.

Original languageEnglish (US)
Pages (from-to)997-1002
Number of pages6
JournalPeptides
Volume8
Issue number6
DOIs
StatePublished - 1987

Bibliographical note

Funding Information:
This work was supported in part by the Ontario Mental Health Foundation, and the National Institute of Health (NS 20036), USA. We thank Mrs. Sara DeSilvio for her meticulous typing of this manuscript.

Keywords

  • 17β Estradiol
  • Antagonism
  • Density increase
  • Dopamine receptor
  • MIF-1
  • Mesolimbic area
  • Striatum

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