17β Estradiol-induced increase in brain dopamine D-2 receptor: Antagonism by MIF-1

G. Rajakumar, P. Chiu, S. Chiu, R. L. Johnson, R. K. Mishra

Research output: Contribution to journalArticle

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Abstract

Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17β-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.

Original languageEnglish (US)
Pages (from-to)997-1002
Number of pages6
JournalPeptides
Volume8
Issue number6
DOIs
StatePublished - Jan 1 1987

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Keywords

  • 17β Estradiol
  • Antagonism
  • Density increase
  • Dopamine receptor
  • MIF-1
  • Mesolimbic area
  • Striatum

Cite this

Rajakumar, G., Chiu, P., Chiu, S., Johnson, R. L., & Mishra, R. K. (1987). 17β Estradiol-induced increase in brain dopamine D-2 receptor: Antagonism by MIF-1. Peptides, 8(6), 997-1002. https://doi.org/10.1016/0196-9781(87)90127-6