17β Estradiol-induced increase in brain dopamine D-2 receptor: Antagonism by MIF-1

G. Rajakumar; P. Chiu; S. Chiu; R. L. Johnson; R. K. Mishra

doi:10.1016/0196-9781(87)90127-6

17β Estradiol-induced increase in brain dopamine D-2 receptor: Antagonism by MIF-1

G. Rajakumar, P. Chiu, S. Chiu, R. L. Johnson, R. K. Mishra

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17β-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.

Original language	English (US)
Pages (from-to)	997-1002
Number of pages	6
Journal	Peptides
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(87)90127-6
State	Published - 1987
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported in part by the Ontario Mental Health Foundation, and the National Institute of Health (NS 20036), USA. We thank Mrs. Sara DeSilvio for her meticulous typing of this manuscript.

Keywords

17β Estradiol
Antagonism
Density increase
Dopamine receptor
MIF-1
Mesolimbic area
Striatum

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10.1016/0196-9781(87)90127-6

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title = "17β Estradiol-induced increase in brain dopamine D-2 receptor: Antagonism by MIF-1",

abstract = "Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17β-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.",

keywords = "17β Estradiol, Antagonism, Density increase, Dopamine receptor, MIF-1, Mesolimbic area, Striatum",

author = "G. Rajakumar and P. Chiu and S. Chiu and Johnson, {R. L.} and Mishra, {R. K.}",

note = "Funding Information: This work was supported in part by the Ontario Mental Health Foundation, and the National Institute of Health (NS 20036), USA. We thank Mrs. Sara DeSilvio for her meticulous typing of this manuscript.",

year = "1987",

doi = "10.1016/0196-9781(87)90127-6",

language = "English (US)",

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pages = "997--1002",

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T1 - 17β Estradiol-induced increase in brain dopamine D-2 receptor

T2 - Antagonism by MIF-1

AU - Rajakumar, G.

AU - Chiu, P.

AU - Chiu, S.

AU - Johnson, R. L.

AU - Mishra, R. K.

N1 - Funding Information: This work was supported in part by the Ontario Mental Health Foundation, and the National Institute of Health (NS 20036), USA. We thank Mrs. Sara DeSilvio for her meticulous typing of this manuscript.

PY - 1987

Y1 - 1987

N2 - Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17β-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.

AB - Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17β-estradiol, antagonized significantly the estrogen-induced increase in the density of dopamine D-2 receptor both in the striatum and the mesolimbic area of male rat brain. The current findings have implications for the prophylactic and therapeutic potential for MIF-1 in extrapyramidal motor disorders caused by estrogen imbalance in humans.

KW - 17β Estradiol

KW - Antagonism

KW - Density increase

KW - Dopamine receptor

KW - MIF-1

KW - Mesolimbic area

KW - Striatum

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DO - 10.1016/0196-9781(87)90127-6

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ER -

17β Estradiol-induced increase in brain dopamine D-2 receptor: Antagonism by MIF-1

Abstract

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Keywords

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