15-methylation augments the cardiovascular effects of prostaglandin F

E. K. Weir, J. T. Reeves, W. Droegemueller, R. F. Grover

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Intramuscular injection of the 15-methyl analogue of prostaglandin F (15-me-PGF) is being used to initiate second trimester abortion. The natural prostaglandin F (PGF) is a known pulmonary pressor agent but there is little information about the cardiovascular effects of the analogue. Consequently, we compared the hemodynamic responses to the two forms in twenty-three anesthetized dogs. Given I.M. or I.V. 15-me-PGF produced a greater and more sustained rise in pulmonary arterial pressure than PG F. Intramuscular 15-me-PGF also elicited a more prolonged increase in pulmonary vascular resistance than prostaglandin F given I.M. or I.V. The methyl analogue (I.M. or I.V.) causes a greater initial fall in systemic arterial oxygen tension and cardiac output, and a greater increase in systemic resistance than I.M. PG F Breathlessness seen during abortion induced by prostaglandin F or its methyl analogue may be caused by acute pulmonary hypertension in addition to bronchoconstriction.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalProstaglandins
Volume9
Issue number3
DOIs
StatePublished - Mar 1975

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