1,5-diphenylpenta-1,4 dien-3-ones: A novel class of free radical scavengers

Nagaraja Naik, H. Vijay Kumar, S. Swetha

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A series of 1,5-diphenylpenta-1,4-dien-3-ones were synthesized by conjugating benzalacetone with different substituted benzaldehydes. The general synthetic strategy employed for the synthesis of the compounds was based on mixed aldol condensation reaction in the presence of strong base. The structures of newly synthesized compounds were characterized by spectral and elemental analysis. Their radical scavenging activity was evaluated through the determination of their abilities to inhibit free radicals using DPPH. as a stable radical. Ascorbic acid (AA) was used as reference antioxidant compound and also the comparative study with the synthesized compounds were done. The compounds that showed potential antioxidant activity based on IC 50 value from the highest level were: 2e, 2b and 2a.

Original languageEnglish (US)
Pages (from-to)460-464
Number of pages5
JournalBulgarian Chemical Communications
Issue number3
StatePublished - Dec 1 2011


  • Aldehydes and radical scavenging activity
  • Benzalacetone


Dive into the research topics of '1,5-diphenylpenta-1,4 dien-3-ones: A novel class of free radical scavengers'. Together they form a unique fingerprint.

Cite this