A series of 1,5-diphenylpenta-1,4-dien-3-ones were synthesized by conjugating benzalacetone with different substituted benzaldehydes. The general synthetic strategy employed for the synthesis of the compounds was based on mixed aldol condensation reaction in the presence of strong base. The structures of newly synthesized compounds were characterized by spectral and elemental analysis. Their radical scavenging activity was evaluated through the determination of their abilities to inhibit free radicals using DPPH. as a stable radical. Ascorbic acid (AA) was used as reference antioxidant compound and also the comparative study with the synthesized compounds were done. The compounds that showed potential antioxidant activity based on IC 50 value from the highest level were: 2e, 2b and 2a.
|Original language||English (US)|
|Number of pages||5|
|Journal||Bulgarian Chemical Communications|
|State||Published - Dec 1 2011|
- Aldehydes and radical scavenging activity