Abstract
The 14-hydroxy group is known to increase the antagonist potency of μ- selective opioid ligands. To investigate the role of this group at the δ opioid receptor, the 14-desoxy analogues (7 and 9) of the δ-selective ligands, naltrindole (1, NT1) and spiroindanyloxymorphone (2, SIOM), have been synthesized and tested. The in vitro pharmacologic activities of 7 and 9 suggest that the 14-hydroxy group plays an important role in determining the δ selectivity and potency of NT1 and SIOM.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2657-2660 |
| Number of pages | 4 |
| Journal | Journal of medicinal chemistry |
| Volume | 41 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 2 1998 |
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