1,2,4-Trifunctionalized Cyclohexane Synthesis via a Diastereoselective Reductive Cope Rearrangement and Functional Group Interconversion Strategy

Michael D. Mannchen, Ion Ghiviriga, Khalil A. Abboud, Alexander J. Grenning

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Polyfunctionalized cyclohexanes are privileged scaffolds in drug discovery. Reported herein is a method for synthesizing 1,2,4-trifunctionalized cyclohexanes via diastereoselective reductive Cope rearrangement. The scaffolds obtained can be derivatized by orthogonal functional group interconversion to cyclohexanes bearing a 1-amide, 2-branched arylallyl, and variable 4-functional group.

Original languageEnglish (US)
Pages (from-to)8804-8809
Number of pages6
JournalOrganic Letters
Volume23
Issue number22
DOIs
StatePublished - Nov 19 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society.

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