1,2,4-Triazole Amino Nucleosides. 1-β-d-3′-Amino-3′-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide And Related Nucleosides

A. S. Narang, Robert Vince

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The synthesis of l-β-d-3′-amino-3′-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide—the 3′-amino analogue of ribavirin-and five related nucleoside analogues is described. Each analogue exhibited LD50 concentrations : 100 μg/mL against P-388 mouse lymphoid leukemia cells in tissue culture. Antiviral testing indicated that none of the compounds exhibited significant activity.

Original languageEnglish (US)
Pages (from-to)1684-1687
Number of pages4
JournalJournal of medicinal chemistry
Volume20
Issue number12
DOIs
StatePublished - Dec 1 1977

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