1,2,4-Triazole Amino Nucleosides. 1-β-d-3′-Amino-3′-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide And Related Nucleosides

The synthesis of l-β-d-3′-amino-3′-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide—the 3′-amino analogue of ribavirin-and five related nucleoside analogues is described. Each analogue exhibited LD₅₀ concentrations : 100 μg/mL against P-388 mouse lymphoid leukemia cells in tissue culture. Antiviral testing indicated that none of the compounds exhibited significant activity.