1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinöhl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG.

Original languageEnglish (US)
Pages (from-to)19-34
Number of pages16
JournalJACC: Basic to Translational Science
Issue number1
StatePublished - Jan 2023

Bibliographical note

Funding Information:
The authors thank the team at American Preclinical Services.

Publisher Copyright:
© 2023 The Authors


  • coronary artery bypass graft
  • coronary artery disease
  • coronary revascularization
  • polymeric bypass graft
  • preclinical model
  • quantitative flow ratio
  • restorative vascular graft

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of '1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model'. Together they form a unique fingerprint.

Cite this