06-Methylguanine Is a Critical Determinant of 4-(Methylnitrosamino)-l- (3-pyridyl)-l-butanone Tumorigenesis in A/J Mouse Lung

Lisa A. Peterson; Stephen S. Hecht

06-Methylguanine Is a Critical Determinant of 4-(Methylnitrosamino)-l- (3-pyridyl)-l-butanone Tumorigenesis in A/J Mouse Lung

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Abstract

The relative importance of the two a-hydroxylation pathways in the tumorigenicity of the tobacco-specific nitrosamine, 4-(methylnitrosamino)- l-(3-pyridyl)-l-butanone(NNK), was examined in the A/J mouse lung. Methyl hydroxylation, which results in DNA pyridyloxobutylation, was investigated with 4-(acetoxymethylnitrosamino)-l-(3-pyridyl)-1-butanone (NNKOAc) and N'-nitrosonornicotine. MÃ

Original language	English (US)
Pages (from-to)	5557-5564
Number of pages	8
Journal	Cancer Research
Volume	51
Issue number	20
State	Published - Oct 1991

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abstract = "The relative importance of the two a-hydroxylation pathways in the tumorigenicity of the tobacco-specific nitrosamine, 4-(methylnitrosamino)- l-(3-pyridyl)-l-butanone(NNK), was examined in the A/J mouse lung. Methyl hydroxylation, which results in DNA pyridyloxobutylation, was investigated with 4-(acetoxymethylnitrosamino)-l-(3-pyridyl)-1-butanone (NNKOAc) and N'-nitrosonornicotine. M{\~A}",

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AU - Hecht, Stephen S.

PY - 1991/10

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N2 - The relative importance of the two a-hydroxylation pathways in the tumorigenicity of the tobacco-specific nitrosamine, 4-(methylnitrosamino)- l-(3-pyridyl)-l-butanone(NNK), was examined in the A/J mouse lung. Methyl hydroxylation, which results in DNA pyridyloxobutylation, was investigated with 4-(acetoxymethylnitrosamino)-l-(3-pyridyl)-1-butanone (NNKOAc) and N'-nitrosonornicotine. MÃ

AB - The relative importance of the two a-hydroxylation pathways in the tumorigenicity of the tobacco-specific nitrosamine, 4-(methylnitrosamino)- l-(3-pyridyl)-l-butanone(NNK), was examined in the A/J mouse lung. Methyl hydroxylation, which results in DNA pyridyloxobutylation, was investigated with 4-(acetoxymethylnitrosamino)-l-(3-pyridyl)-1-butanone (NNKOAc) and N'-nitrosonornicotine. MÃ

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ER -

06-Methylguanine Is a Critical Determinant of 4-(Methylnitrosamino)-l- (3-pyridyl)-l-butanone Tumorigenesis in A/J Mouse Lung

Abstract

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