Abstract
The relative importance of the two a-hydroxylation pathways in the tumorigenicity of the tobacco-specific nitrosamine, 4-(methylnitrosamino)- l-(3-pyridyl)-l-butanone(NNK), was examined in the A/J mouse lung. Methyl hydroxylation, which results in DNA pyridyloxobutylation, was investigated with 4-(acetoxymethylnitrosamino)-l-(3-pyridyl)-1-butanone (NNKOAc) and N'-nitrosonornicotine. MÃ
Original language | English (US) |
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Pages (from-to) | 5557-5564 |
Number of pages | 8 |
Journal | Cancer Research |
Volume | 51 |
Issue number | 20 |
State | Published - Oct 1991 |