μ-Opioid receptor-knockout mice: The role of μ-opioid receptor in gastrointestinal transit

Sabita Roy, Hsien Ching Liu, Horace H Loh

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87 Scopus citations

Abstract

The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalMolecular Brain Research
Volume56
Issue number1-2
DOIs
StatePublished - May 1998

Bibliographical note

Funding Information:
This work was supported by NIH grants DA00564, DA01583, DA05695, K05-DA70554, F. and A. Stark Fund (MMF)-HHL and DA08188 (SR).

Keywords

  • Gastrointestinal motility
  • Knockout
  • Morphine
  • μ-Opioid receptor

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