δ-opioid receptors inhibit neurogenic intestinal secretion evoked by mast cell degranulation and type I hypersensitivity

Sutthasinee Poonyachoti, David R Brown

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Histamine and the mast cell degranulator, compound 48/80 produced elevations in short-circuit current, an electrical measure of active anion secretion, across porcine ileal mucosa sheets mounted in Ussing chambers. Luminally-applied β-lactoglobulin produced similar effects in mucosal sheets from cow's milk-sensitized pigs. Their secretory effects were attenuated by blockers of H1-histamine receptors, neuronal conduction or epithelial Na+/K+/Cl- cotransport. The δ-opioid agonist [D-Pen2,D-Pen5]enkephalin suppressed mucosal responses to these substances in a naltrindole-reversible manner. Furthermore, submucosal mast cells and δ-opioid receptor-immunoreactive nerve fibers were observed in close juxtaposition. Intestinal neural pathways linking immediate hypersensitivity to secretory host defense appear to express inhibitory δ-opioid receptors. (C) 2001 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalJournal of Neuroimmunology
Volume112
Issue number1-2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Enkephalin
  • Food allergy
  • Ileum
  • Pharmaconeuroimmunology
  • Pig

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