β‐ENDORPHIN: SYNTHESIS AND MORPHINE‐LIKE ACTIVITY OF ANALOGS WITH D‐AMINO ACID RESIDUES IN POSITIONS 1, 2, 4 AND 5

Donald Yamashiro, Liang‐Fu ‐F Tseng, Byron A. Doneen, Horace H. Loh, Choh Hao Li

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The solid‐phase syntheses of [D‐Tyr1]‐, [D‐Ala2]‐, [D‐Phe4]‐, and [D‐Met5]‐βc‐endorphins are described. A comparison of certain methods of purification and criteria of homogeneity is made with the use of these compounds. Bioassay of these synthetic analogs both in vitro and in vivo show that [D‐Ala2]‐βc‐endorphin possesses significant opiate activity whereas the other analogs have minimal activity.

Original languageEnglish (US)
Pages (from-to)159-166
Number of pages8
JournalInternational Journal of Peptide and Protein Research
Volume10
Issue number2
DOIs
StatePublished - Aug 1977

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