The solid‐phase syntheses of [D‐Tyr1]‐, [D‐Ala2]‐, [D‐Phe4]‐, and [D‐Met5]‐βc‐endorphins are described. A comparison of certain methods of purification and criteria of homogeneity is made with the use of these compounds. Bioassay of these synthetic analogs both in vitro and in vivo show that [D‐Ala2]‐βc‐endorphin possesses significant opiate activity whereas the other analogs have minimal activity.
|Original language||English (US)|
|Number of pages||8|
|Journal||International Journal of Peptide and Protein Research|
|State||Published - Aug 1977|