β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF SHORTENED PEPTIDE CHAINS

Choh Hao Li, Donald Yamashiro, Liang‐Fu ‐F Tseng, Horace H. Loh

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Three analogs of β‐endorphin have been synthesized by the solid‐phase method: βc‐endorphin‐(1–5)‐(28–31), βc‐endorphin‐(6–31) and βh‐endorphin‐(1–5)‐(16–31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than β‐endorphin. These data suggest that the entire β‐endorphin molecule is necessary for full in vivo analgesic activity.

Original languageEnglish (US)
Pages (from-to)154-158
Number of pages5
JournalInternational Journal of Peptide and Protein Research
Volume11
Issue number2
DOIs
StatePublished - Feb 1978

Keywords

  • analgesia
  • enkephalin
  • morphine‐like
  • opiates
  • peptide
  • synthesis
  • β‐endorphin

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