Three analogs of β‐endorphin have been synthesized by the solid‐phase method: βc‐endorphin‐(1–5)‐(28–31), βc‐endorphin‐(6–31) and βh‐endorphin‐(1–5)‐(16–31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than β‐endorphin. These data suggest that the entire β‐endorphin molecule is necessary for full in vivo analgesic activity.
|Original language||English (US)|
|Number of pages||5|
|Journal||International Journal of Peptide and Protein Research|
|State||Published - Feb 1978|