β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF SHORTENED PEPTIDE CHAINS

Choh Hao Li; Donald Yamashiro; Liang‐Fu ‐F Tseng; Horace H. Loh

doi:10.1111/j.1399-3011.1978.tb02834.x

β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF SHORTENED PEPTIDE CHAINS

Choh Hao Li, Donald Yamashiro, Liang‐Fu ‐F Tseng, Horace H. Loh

Pharmacology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Three analogs of β‐endorphin have been synthesized by the solid‐phase method: β_c‐endorphin‐(1–5)‐(28–31), β_c‐endorphin‐(6–31) and β_h‐endorphin‐(1–5)‐(16–31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than β‐endorphin. These data suggest that the entire β‐endorphin molecule is necessary for full in vivo analgesic activity.

Original language	English (US)
Pages (from-to)	154-158
Number of pages	5
Journal	International Journal of Peptide and Protein Research
Volume	11
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-3011.1978.tb02834.x
State	Published - Feb 1978

Keywords

analgesia
enkephalin
morphine‐like
opiates
peptide
synthesis
β‐endorphin

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10.1111/j.1399-3011.1978.tb02834.x

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title = "β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF SHORTENED PEPTIDE CHAINS",

abstract = "Three analogs of β‐endorphin have been synthesized by the solid‐phase method: βc‐endorphin‐(1–5)‐(28–31), βc‐endorphin‐(6–31) and βh‐endorphin‐(1–5)‐(16–31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than β‐endorphin. These data suggest that the entire β‐endorphin molecule is necessary for full in vivo analgesic activity.",

keywords = "analgesia, enkephalin, morphine‐like, opiates, peptide, synthesis, β‐endorphin",

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year = "1978",

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AU - Li, Choh Hao

AU - Yamashiro, Donald

AU - Tseng, Liang‐Fu ‐F

AU - Loh, Horace H.

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AB - Three analogs of β‐endorphin have been synthesized by the solid‐phase method: βc‐endorphin‐(1–5)‐(28–31), βc‐endorphin‐(6–31) and βh‐endorphin‐(1–5)‐(16–31). The analgesic activities of these synthetic peptides relative to that of the parent molecule are reported. All three peptides at high doses exhibit either no or much weaker analgesic activity than β‐endorphin. These data suggest that the entire β‐endorphin molecule is necessary for full in vivo analgesic activity.

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KW - morphine‐like

KW - opiates

KW - peptide

KW - synthesis

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β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF SHORTENED PEPTIDE CHAINS

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