β h‐ENDORPHIN: ANTIDIURETIC EFFECTS IN RATS

Liang‐Fu ‐F Tseng, Horace H. Loh, Choh Hao Li

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Human β‐endorphin (βh‐EP) inhibits urine flow in rats. This antidiuretic effect of the peptide occurs after intravenous and intraventricular injections. Intravenously, βh‐EP is 24 times more potent than morphine. Intraventricularly, βh‐EP is 24 times more potent than morphine. Intraventricularly, βh‐EP is effective at doses (0.45 μg) which have no antidiuretic activity when injected intravenously. This fact suggests that one site of the antidiuretic action of βh‐endorphin may be in the central nervous system. Animals tolerant to morphine are also tolerant to the antidiuretic effects of βh‐endorphin.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalInternational Journal of Peptide and Protein Research
Volume12
Issue number3
DOIs
StatePublished - Sep 1978

Keywords

  • antidiuretic action
  • β‐endorphin

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