β-GLUCURONIDASE AND HYPERBILIRUBINAEMIA IN BREAST-FED AND FORMULA-FED BABIES

G. R. Gourley, R. A. Arend

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Breast milk or formula milk and serum samples from 34 breast-fed babies, 15 formula-fed babies, and their mothers were examined at 3 and 21 days of neonatal age. Infant faecal samples were obtained on day 21 only. At both ages serum total bilirubin concentrations were significantly higher in breast-fed than in formula-fed infants. β-glucuronidase activity in formula milk was negligible while that in human milk was considerable. Day 21 faecal β-glucuronidase was higher in the breast-fed babies. In the breast-fed babies, serum bilirubin levels were related to concentrations of β-glucuronidase in breast milk on both days 3 and 21 and to levels of faecal β-glucuronidase on day 21. In 4 additional babies whose feeds were temporarily changed from breast milk to formula milk because of hyperbilirubinaemia there was a striking decrease in faecal β-glucuronidase activity coincident with a fall in serum bilirubin. Breast milk β-glucuronidase seems to be an important factor in the neonatal hyperbilirubinaemia of breast-fed babies.

Original languageEnglish (US)
Pages (from-to)644-646
Number of pages3
JournalThe Lancet
Volume327
Issue number8482
DOIs
StatePublished - Mar 22 1986

Bibliographical note

Funding Information:
We thank Elizabeth Hoinville, London School of Hygiene and Tropical Medicine, for statistical analysis. This study was supported partly by a grant from North West Thames Regional Health Authority, and by Boots Company plc, which also provided the drugs and helped construct the therapeutic trial.

Fingerprint

Dive into the research topics of 'β-GLUCURONIDASE AND HYPERBILIRUBINAEMIA IN BREAST-FED AND FORMULA-FED BABIES'. Together they form a unique fingerprint.

Cite this