β-Fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: The Atherosclerosis Risk in Communities (ARIC) Study

Aaron R. Folsom; Nena Aleksic; Chul Ahn; Eric Boerwinkle; Kenneth K. Wu

doi:10.1016/S1047-2797(00)00203-9

β-Fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: The Atherosclerosis Risk in Communities (ARIC) Study

Aaron R. Folsom, Nena Aleksic, Chul Ahn, Eric Boerwinkle, Kenneth K. Wu

Epidemiology & Community Health

Research output: Contribution to journal › Letter › peer-review

39 Scopus citations

Abstract

PURPOSE: The -455G/A (HaeIII) polymorphism of the β-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease. METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -455G/A status with a random sample of the cohort (n = 498). RESULTS: Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD. CONCLUSIONS: Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD.

Original language	English (US)
Pages (from-to)	166-170
Number of pages	5
Journal	Annals of epidemiology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/S1047-2797(00)00203-9
State	Published - Jan 1 2001

Keywords

Coronary disease
Fibrinogen
Prospective study

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10.1016/S1047-2797(00)00203-9

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title = "β-Fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: The Atherosclerosis Risk in Communities (ARIC) Study",

abstract = "PURPOSE: The -455G/A (HaeIII) polymorphism of the β-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease. METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -455G/A status with a random sample of the cohort (n = 498). RESULTS: Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD. CONCLUSIONS: Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD.",

keywords = "Coronary disease, Fibrinogen, Prospective study",

author = "Folsom, {Aaron R.} and Nena Aleksic and Chul Ahn and Eric Boerwinkle and Wu, {Kenneth K.}",

year = "2001",

month = jan,

day = "1",

doi = "10.1016/S1047-2797(00)00203-9",

language = "English (US)",

volume = "11",

pages = "166--170",

journal = "Annals of Epidemiology",

issn = "1047-2797",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - β-Fibrinogen gene -455G/A polymorphism and coronary heart disease incidence

T2 - The Atherosclerosis Risk in Communities (ARIC) Study

AU - Folsom, Aaron R.

AU - Aleksic, Nena

AU - Ahn, Chul

AU - Boerwinkle, Eric

AU - Wu, Kenneth K.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - PURPOSE: The -455G/A (HaeIII) polymorphism of the β-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease. METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -455G/A status with a random sample of the cohort (n = 498). RESULTS: Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD. CONCLUSIONS: Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD.

AB - PURPOSE: The -455G/A (HaeIII) polymorphism of the β-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease. METHODS: We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -455G/A status with a random sample of the cohort (n = 498). RESULTS: Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD. CONCLUSIONS: Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD.

KW - Coronary disease

KW - Fibrinogen

KW - Prospective study

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U2 - 10.1016/S1047-2797(00)00203-9

DO - 10.1016/S1047-2797(00)00203-9

M3 - Letter

C2 - 11293402

AN - SCOPUS:0035117844

SN - 1047-2797

VL - 11

SP - 166

EP - 170

JO - Annals of Epidemiology

JF - Annals of Epidemiology

IS - 3

ER -

β-Fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: The Atherosclerosis Risk in Communities (ARIC) Study

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