TY - JOUR
T1 - β Endorphin is a potent analgesic agent
AU - Loh, H. H.
AU - Tseng, L. F.
AU - Wei, E.
AU - Hao Li, C.
PY - 1976
Y1 - 1976
N2 - β Endorphin, an opiate like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the tail flick, hot plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, β endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of β endorphin in vivo is also compared to other peptides that show opiate like activity in assays in vitro.
AB - β Endorphin, an opiate like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the tail flick, hot plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, β endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of β endorphin in vivo is also compared to other peptides that show opiate like activity in assays in vitro.
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U2 - 10.1073/pnas.73.8.2895
DO - 10.1073/pnas.73.8.2895
M3 - Article
C2 - 8780
AN - SCOPUS:0003269808
SN - 0027-8424
VL - 73
SP - 2895
EP - 2898
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 8
ER -