β Endorphin is a potent analgesic agent

H. H. Loh, L. F. Tseng, E. Wei, C. Hao Li

Research output: Contribution to journalArticlepeer-review

381 Scopus citations

Abstract

β Endorphin, an opiate like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the tail flick, hot plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, β endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of β endorphin in vivo is also compared to other peptides that show opiate like activity in assays in vitro.

Original languageEnglish (US)
Pages (from-to)2895-2898
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number8
DOIs
StatePublished - 1976

Fingerprint Dive into the research topics of 'β Endorphin is a potent analgesic agent'. Together they form a unique fingerprint.

Cite this