β-endorphin in vitro inhibition of striatal dopamine release

Horace H. Loh; David A. Brase; Sumathy Sampath-Khanna; Jeffrey B. Mar; E. Leong Way; Choh Hao Li

doi:10.1038/264567a0

β-endorphin in vitro inhibition of striatal dopamine release

Horace H. Loh
, David A. Brase
, Sumathy Sampath-Khanna
, Jeffrey B. Mar
, E. Leong Way
, Choh Hao Li

Pharmacology

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

THERE has been considerable recent interest in endogenous peptides as possible analgesic agents since the isolation of a pentapeptide with opiate-like activity (methionine-enkephalin) from porcine brain¹. Of particular interest is β-endorphin, isolated from camel pituitary glands², and now synthesised³. We report here the inhibitory effect in vitro of β-endorphin on striatal dopamine release from the central nervous system (CNS).

Original language	English (US)
Pages (from-to)	567-568
Number of pages	2
Journal	Nature
Volume	264
Issue number	5586
DOIs	https://doi.org/10.1038/264567a0
State	Published - 1976

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abstract = "THERE has been considerable recent interest in endogenous peptides as possible analgesic agents since the isolation of a pentapeptide with opiate-like activity (methionine-enkephalin) from porcine brain1. Of particular interest is β-endorphin, isolated from camel pituitary glands2, and now synthesised3. We report here the inhibitory effect in vitro of β-endorphin on striatal dopamine release from the central nervous system (CNS).",

author = "Loh, \{Horace H.\} and Brase, \{David A.\} and Sumathy Sampath-Khanna and Mar, \{Jeffrey B.\} and Way, \{E. Leong\} and Li, \{Choh Hao\}",

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doi = "10.1038/264567a0",

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journal = "Nature",

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T1 - β-endorphin in vitro inhibition of striatal dopamine release

AU - Loh, Horace H.

AU - Brase, David A.

AU - Sampath-Khanna, Sumathy

AU - Mar, Jeffrey B.

AU - Way, E. Leong

AU - Li, Choh Hao

PY - 1976

Y1 - 1976

N2 - THERE has been considerable recent interest in endogenous peptides as possible analgesic agents since the isolation of a pentapeptide with opiate-like activity (methionine-enkephalin) from porcine brain1. Of particular interest is β-endorphin, isolated from camel pituitary glands2, and now synthesised3. We report here the inhibitory effect in vitro of β-endorphin on striatal dopamine release from the central nervous system (CNS).

AB - THERE has been considerable recent interest in endogenous peptides as possible analgesic agents since the isolation of a pentapeptide with opiate-like activity (methionine-enkephalin) from porcine brain1. Of particular interest is β-endorphin, isolated from camel pituitary glands2, and now synthesised3. We report here the inhibitory effect in vitro of β-endorphin on striatal dopamine release from the central nervous system (CNS).

UR - https://www.scopus.com/pages/publications/0017189174

UR - https://www.scopus.com/pages/publications/0017189174#tab=citedBy

U2 - 10.1038/264567a0

DO - 10.1038/264567a0

M3 - Article

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VL - 264

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JO - Nature

JF - Nature

IS - 5586

ER -

β-endorphin in vitro inhibition of striatal dopamine release

Abstract

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