β-endorphin in vitro inhibition of striatal dopamine release

Horace H. Loh, David A. Brase, Sumathy Sampath-Khanna, Jeffrey B. Mar, E. Leong Way, Choh Hao Li

Research output: Contribution to journalArticlepeer-review

201 Scopus citations

Abstract

THERE has been considerable recent interest in endogenous peptides as possible analgesic agents since the isolation of a pentapeptide with opiate-like activity (methionine-enkephalin) from porcine brain1. Of particular interest is β-endorphin, isolated from camel pituitary glands2, and now synthesised3. We report here the inhibitory effect in vitro of β-endorphin on striatal dopamine release from the central nervous system (CNS).

Original languageEnglish (US)
Pages (from-to)567-568
Number of pages2
JournalNature
Volume264
Issue number5586
DOIs
StatePublished - 1976

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