β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior

Leonard Lichtblau, Linda H. Fossom, Sheldon B. Sparber

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior.

Original languageEnglish (US)
Pages (from-to)927-932
Number of pages6
JournalLife Sciences
Volume21
Issue number7
DOIs
StatePublished - Oct 1 1977

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