β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior

Leonard Lichtblau; Linda H. Fossom; Sheldon B. Sparber

doi:10.1016/0024-3205(77)90257-0

β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior

Leonard Lichtblau, Linda H. Fossom, Sheldon B. Sparber

Basic Sciences

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Abstract

Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior.

Original language	English (US)
Pages (from-to)	927-932
Number of pages	6
Journal	Life Sciences
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(77)90257-0
State	Published - Oct 1 1977

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abstract = "Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior.",

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AB - Centrally administered β-endorphin or morphine suppressed fixed-ratio 15, food-reinforced responding by rats in a dose- dependent manner. β-Endorphin was 21 times more potent than morphine on a molar basis. Scratching and wet-dog shakes were observed within 30 minutes of β-endorphin administration but were not seen after morphine and did not appear to be responsible for the suppression of the conditioned behavior.

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β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior

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