β Endorphin: behavioral and analgesic activity in cats

M. Meglio; Y. Hosobuchi; H. H. Loh; J. E. Adams; C. H. Li

doi:10.1073/pnas.74.2.774

β Endorphin: behavioral and analgesic activity in cats

M. Meglio, Y. Hosobuchi, H. H. Loh, J. E. Adams, C. H. Li

Pharmacology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

β Endorphin has been shown to possess potent behavioral and antinociceptive activities when administered intraventricularly in cats. On a molar basis, β endorphin is 72-96 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone.

Original language	English (US)
Pages (from-to)	774-776
Number of pages	3
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	74
Issue number	2
DOIs	https://doi.org/10.1073/pnas.74.2.774
State	Published - 1977

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10.1073/pnas.74.2.774

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title = "β Endorphin: behavioral and analgesic activity in cats",

abstract = "β Endorphin has been shown to possess potent behavioral and antinociceptive activities when administered intraventricularly in cats. On a molar basis, β endorphin is 72-96 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone.",

author = "M. Meglio and Y. Hosobuchi and Loh, {H. H.} and Adams, {J. E.} and Li, {C. H.}",

year = "1977",

doi = "10.1073/pnas.74.2.774",

language = "English (US)",

volume = "74",

pages = "774--776",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

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TY - JOUR

T1 - β Endorphin

T2 - behavioral and analgesic activity in cats

AU - Meglio, M.

AU - Hosobuchi, Y.

AU - Loh, H. H.

AU - Adams, J. E.

AU - Li, C. H.

PY - 1977

Y1 - 1977

N2 - β Endorphin has been shown to possess potent behavioral and antinociceptive activities when administered intraventricularly in cats. On a molar basis, β endorphin is 72-96 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone.

AB - β Endorphin has been shown to possess potent behavioral and antinociceptive activities when administered intraventricularly in cats. On a molar basis, β endorphin is 72-96 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone.

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DO - 10.1073/pnas.74.2.774

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AN - SCOPUS:0017352512

SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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β Endorphin: behavioral and analgesic activity in cats

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